SMR3B_HUMAN
ID SMR3B_HUMAN Reviewed; 79 AA.
AC P02814; B7ZMG7; Q9UBN0; Q9UCT0;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Submaxillary gland androgen-regulated protein 3B;
DE AltName: Full=Proline-rich peptide P-B;
DE AltName: Full=Proline-rich protein 3;
DE Contains:
DE RecName: Full=Peptide P-A;
DE Contains:
DE RecName: Full=Peptide D1A;
DE Flags: Precursor;
GN Name=SMR3B; Synonyms=PBII, PRL3, PROL3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Submandibular gland;
RX PubMed=7982889; DOI=10.1093/oxfordjournals.jbchem.a124464;
RA Isemura S., Saito E.;
RT "Molecular cloning and sequence analysis of cDNA coding for the precursor
RT of the human salivary proline-rich peptide P-B.";
RL J. Biochem. 115:1101-1106(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RX PubMed=10731710; DOI=10.1093/oxfordjournals.jbchem.a022620;
RA Isemura S.;
RT "Nucleotide sequence of gene PBII encoding salivary proline-rich protein P-
RT B.";
RL J. Biochem. 127:393-398(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Duodenum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 23-79, AND PYROGLUTAMATE FORMATION AT GLN-23.
RC TISSUE=Saliva;
RX PubMed=479131;
RA Isemura S., Saitoh E., Sanada K.;
RT "Isolation and amino acid sequences of proline-rich peptides of human whole
RT saliva.";
RL J. Biochem. 86:79-86(1979).
RN [6]
RP PROTEIN SEQUENCE OF 30-43.
RC TISSUE=Saliva;
RX PubMed=1747107; DOI=10.1042/bj2800341;
RA Ramasubbu N., Reddy M.S., Bergey E.J., Haraszthy G.G., Soni S.-D.,
RA Levine M.J.;
RT "Large-scale purification and characterization of the major phosphoproteins
RT and mucins of human submandibular-sublingual saliva.";
RL Biochem. J. 280:341-352(1991).
CC -!- INTERACTION:
CC P02814; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-738612, EBI-748420;
CC P02814; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-738612, EBI-741480;
CC P02814; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-738612, EBI-10173939;
CC P02814; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-738612, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Secreted into saliva by submaxillary gland. Not
CC expressed in heart, brain, lung, liver, skeletal muscle, Kidney,
CC pancreas or placenta. {ECO:0000269|PubMed:7982889}.
CC -!- PTM: P-A and D1A are probably degradation products of P-B.
CC -!- SIMILARITY: Belongs to the PROL1/PROL3 family. {ECO:0000305}.
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DR EMBL; D29833; BAA06213.1; -; mRNA.
DR EMBL; AB031740; BAA88517.1; -; Genomic_DNA.
DR EMBL; CH471057; EAX05619.1; -; Genomic_DNA.
DR EMBL; BC015327; AAH15327.1; -; mRNA.
DR EMBL; BC144529; AAI44530.1; -; mRNA.
DR CCDS; CCDS3540.1; -.
DR PIR; JX0321; PJHUSB.
DR RefSeq; NP_006676.1; NM_006685.3.
DR AlphaFoldDB; P02814; -.
DR BioGRID; 116087; 34.
DR IntAct; P02814; 16.
DR MINT; P02814; -.
DR STRING; 9606.ENSP00000302400; -.
DR BioMuta; SMR3B; -.
DR jPOST; P02814; -.
DR MassIVE; P02814; -.
DR MaxQB; P02814; -.
DR PaxDb; P02814; -.
DR PeptideAtlas; P02814; -.
DR PRIDE; P02814; -.
DR ProteomicsDB; 51605; -.
DR TopDownProteomics; P02814; -.
DR Antibodypedia; 24325; 15 antibodies from 7 providers.
DR DNASU; 10879; -.
DR Ensembl; ENST00000304915.8; ENSP00000302400.3; ENSG00000171201.12.
DR Ensembl; ENST00000504825.5; ENSP00000423138.1; ENSG00000171201.12.
DR GeneID; 10879; -.
DR KEGG; hsa:10879; -.
DR MANE-Select; ENST00000304915.8; ENSP00000302400.3; NM_006685.4; NP_006676.1.
DR UCSC; uc003hfh.3; human.
DR CTD; 10879; -.
DR DisGeNET; 10879; -.
DR GeneCards; SMR3B; -.
DR HGNC; HGNC:17326; SMR3B.
DR HPA; ENSG00000171201; Tissue enriched (salivary).
DR MIM; 611593; gene.
DR neXtProt; NX_P02814; -.
DR OpenTargets; ENSG00000171201; -.
DR PharmGKB; PA33805; -.
DR VEuPathDB; HostDB:ENSG00000171201; -.
DR eggNOG; ENOG502TF4A; Eukaryota.
DR GeneTree; ENSGT01010000224746; -.
DR HOGENOM; CLU_2694207_0_0_1; -.
DR InParanoid; P02814; -.
DR OMA; QPYGPGR; -.
DR PathwayCommons; P02814; -.
DR SignaLink; P02814; -.
DR BioGRID-ORCS; 10879; 16 hits in 1052 CRISPR screens.
DR ChiTaRS; SMR3B; human.
DR GenomeRNAi; 10879; -.
DR Pharos; P02814; Tdark.
DR PRO; PR:P02814; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; P02814; protein.
DR Bgee; ENSG00000171201; Expressed in parotid gland and 93 other tissues.
DR Genevisible; P02814; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0051930; P:regulation of sensory perception of pain; IBA:GO_Central.
DR InterPro; IPR026288; SMR-like.
DR PANTHER; PTHR14179; PTHR14179; 1.
DR Pfam; PF15621; PROL5-SMR; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Pyrrolidone carboxylic acid; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:479131"
FT CHAIN 23..79
FT /note="Submaxillary gland androgen-regulated protein 3B"
FT /id="PRO_0000022112"
FT PEPTIDE 30..43
FT /note="Peptide D1A"
FT /id="PRO_0000022113"
FT PEPTIDE 42..79
FT /note="Peptide P-A"
FT /id="PRO_0000022114"
FT REGION 19..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..79
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 23
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:479131"
SQ SEQUENCE 79 AA; 8188 MW; 7B10AE90E95BCB61 CRC64;
MKSLTWILGL WALAACFTPG ESQRGPRGPY PPGPLAPPQP FGPGFVPPPP PPPYGPGRIP
PPPPAPYGPG IFPPPPPQP
