ID   SMR6_ARATH              Reviewed;         112 AA.
AC   Q29Q81; Q8LCF0; Q9FI64;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Cyclin-dependent protein kinase inhibitor SMR6 {ECO:0000303|PubMed:20706207, ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
DE   AltName: Full=Protein SIAMESE-RELATED 6 {ECO:0000303|PubMed:20706207, ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
GN   Name=SMR6 {ECO:0000303|PubMed:20706207, ECO:0000303|PubMed:24399300,
GN   ECO:0000303|PubMed:26546445};
GN   OrderedLocusNames=At5g40460 {ECO:0000312|Araport:AT5G40460};
GN   ORFNames=K21I16.3 {ECO:0000312|EMBL:BAB10495.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:ABD57500.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA   Miyajima N., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT   features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT   clones.";
RL   DNA Res. 6:183-195(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION, INTERACTION WITH CDKA-1 AND D-TYPE CYCLINS, GENE FAMILY, AND
RP   NOMENCLATURE.
RX   PubMed=20706207; DOI=10.1038/msb.2010.53;
RA   Van Leene J., Hollunder J., Eeckhout D., Persiau G., Van De Slijke E.,
RA   Stals H., Van Isterdael G., Verkest A., Neirynck S., Buffel Y., De Bodt S.,
RA   Maere S., Laukens K., Pharazyn A., Ferreira P.C.G., Eloy N., Renne C.,
RA   Meyer C., Faure J.-D., Steinbrenner J., Beynon J., Larkin J.C.,
RA   Van de Peer Y., Hilson P., Kuiper M., De Veylder L., Van Onckelen H.,
RA   Inze D., Witters E., De Jaeger G.;
RT   "Targeted interactomics reveals a complex core cell cycle machinery in
RT   Arabidopsis thaliana.";
RL   Mol. Syst. Biol. 6:397-397(2010).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24399300; DOI=10.1105/tpc.113.118943;
RA   Yi D., Alvim Kamei C.L., Cools T., Vanderauwera S., Takahashi N.,
RA   Okushima Y., Eekhout T., Yoshiyama K.O., Larkin J., Van den Daele H.,
RA   Conklin P., Britt A., Umeda M., De Veylder L.;
RT   "The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5
RT   and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen
RT   species.";
RL   Plant Cell 26:296-309(2014).
RN   [7]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=26546445; DOI=10.1105/tpc.15.00489;
RA   Kumar N., Harashima H., Kalve S., Bramsiepe J., Wang K., Sizani B.L.,
RA   Bertrand L.L., Johnson M.C., Faulk C., Dale R., Simmons L.A.,
RA   Churchman M.L., Sugimoto K., Kato N., Dasanayake M., Beemster G.,
RA   Schnittger A., Larkin J.C.;
RT   "Functional conservation in the SIAMESE-RELATED family of cyclin-dependent
RT   kinase inhibitors in land plants.";
RL   Plant Cell 27:3065-3080(2015).
CC   -!- FUNCTION: Probable cyclin-dependent protein kinase (CDK) inhibitor that
CC       functions as a repressor of mitosis in the endoreduplication cell cycle
CC       (By similarity). May inhibit CDKA-1/CYCD complexes during S-phase,
CC       preventing the re-initiation of DNA replication (PubMed:20706207).
CC       {ECO:0000250|UniProtKB:Q9LZ78, ECO:0000305|PubMed:20706207}.
CC   -!- SUBUNIT: Interacts with CDKA-1 and D-type cyclins (PubMed:20706207).
CC       {ECO:0000269|PubMed:20706207}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB10495.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB017062; BAB10495.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED94550.1; -; Genomic_DNA.
DR   EMBL; BT024675; ABD57500.1; -; mRNA.
DR   EMBL; AY086640; AAM63698.1; -; mRNA.
DR   RefSeq; NP_198862.1; NM_123410.2.
DR   AlphaFoldDB; Q29Q81; -.
DR   IntAct; Q29Q81; 11.
DR   STRING; 3702.AT5G40460.1; -.
DR   PaxDb; Q29Q81; -.
DR   PRIDE; Q29Q81; -.
DR   EnsemblPlants; AT5G40460.1; AT5G40460.1; AT5G40460.
DR   GeneID; 834044; -.
DR   Gramene; AT5G40460.1; AT5G40460.1; AT5G40460.
DR   KEGG; ath:AT5G40460; -.
DR   Araport; AT5G40460; -.
DR   TAIR; locus:2155657; AT5G40460.
DR   eggNOG; ENOG502S1MD; Eukaryota.
DR   HOGENOM; CLU_2226943_0_0_1; -.
DR   InParanoid; Q29Q81; -.
DR   OMA; VEEDCYN; -.
DR   OrthoDB; 1582126at2759; -.
DR   PhylomeDB; Q29Q81; -.
DR   PRO; PR:Q29Q81; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q29Q81; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0045839; P:negative regulation of mitotic nuclear division; IBA:GO_Central.
DR   GO; GO:0032875; P:regulation of DNA endoreduplication; IEA:InterPro.
DR   InterPro; IPR040389; SMR.
DR   PANTHER; PTHR33142; PTHR33142; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Protein kinase inhibitor; Reference proteome.
FT   CHAIN           1..112
FT                   /note="Cyclin-dependent protein kinase inhibitor SMR6"
FT                   /id="PRO_0000438465"
FT   CONFLICT        110
FT                   /note="R -> C (in Ref. 4; AAM63698)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   112 AA;  12708 MW;  EB6E1D77E4939774 CRC64;
     MGFSKKSQFE GGLESDGKKW VIAGISIRAS LKPVKTKLRA PPEIVTEVEE DCYNEEEECS
     TTPTAKETKI PELLECPPAP RKRRPALKCR SNVVREFFTP PSDLETVFLR RR