SMR7_ARATH
ID SMR7_ARATH Reviewed; 99 AA.
AC Q9LVX6; A0MEY7;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Cyclin-dependent protein kinase inhibitor SMR7 {ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
DE AltName: Full=Protein SIAMESE-RELATED 7 {ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
GN Name=SMR7 {ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
GN OrderedLocusNames=At3g27630 {ECO:0000312|Araport:AT3G27630};
GN ORFNames=MGF10.4 {ECO:0000312|EMBL:BAB02687.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAB02687.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION BY DNA DAMAGE AND OXIDATIVE STRESS,
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24399300; DOI=10.1105/tpc.113.118943;
RA Yi D., Alvim Kamei C.L., Cools T., Vanderauwera S., Takahashi N.,
RA Okushima Y., Eekhout T., Yoshiyama K.O., Larkin J., Van den Daele H.,
RA Conklin P., Britt A., Umeda M., De Veylder L.;
RT "The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5
RT and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen
RT species.";
RL Plant Cell 26:296-309(2014).
RN [5]
RP INDUCTION BY IRON.
RX PubMed=25624148; DOI=10.1016/j.molp.2014.11.014;
RA Reyt G., Boudouf S., Boucherez J., Gaymard F., Briat J.F.;
RT "Iron- and ferritin-dependent reactive oxygen species distribution: impact
RT on Arabidopsis root system architecture.";
RL Mol. Plant 8:439-453(2015).
RN [6]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=26546445; DOI=10.1105/tpc.15.00489;
RA Kumar N., Harashima H., Kalve S., Bramsiepe J., Wang K., Sizani B.L.,
RA Bertrand L.L., Johnson M.C., Faulk C., Dale R., Simmons L.A.,
RA Churchman M.L., Sugimoto K., Kato N., Dasanayake M., Beemster G.,
RA Schnittger A., Larkin J.C.;
RT "Functional conservation in the SIAMESE-RELATED family of cyclin-dependent
RT kinase inhibitors in land plants.";
RL Plant Cell 27:3065-3080(2015).
CC -!- FUNCTION: Probable cyclin-dependent protein kinase (CDK) inhibitor that
CC functions as a repressor of mitosis in the endoreduplication cell cycle
CC (PubMed:26546445). Acts as a potent cell cycle inhibitor, regulating a
CC hydroxyurea-dependent checkpoint in leaves (PubMed:24399300).
CC {ECO:0000269|PubMed:24399300, ECO:0000269|PubMed:26546445}.
CC -!- TISSUE SPECIFICITY: Expressed in root meristems after induction.
CC {ECO:0000269|PubMed:24399300}.
CC -!- INDUCTION: Up-regulated by DNA damage and oxidative stress
CC (PubMed:24399300). Down-regulated by iron excess treatment
CC (PubMed:25624148). {ECO:0000269|PubMed:24399300,
CC ECO:0000269|PubMed:25624148}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28223.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB018114; BAB02687.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77346.1; -; Genomic_DNA.
DR EMBL; DQ446707; ABE65490.1; -; Genomic_DNA.
DR EMBL; DQ653110; ABK28223.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_189400.1; NM_113679.2.
DR AlphaFoldDB; Q9LVX6; -.
DR STRING; 3702.AT3G27630.1; -.
DR PaxDb; Q9LVX6; -.
DR PRIDE; Q9LVX6; -.
DR EnsemblPlants; AT3G27630.1; AT3G27630.1; AT3G27630.
DR GeneID; 822385; -.
DR Gramene; AT3G27630.1; AT3G27630.1; AT3G27630.
DR KEGG; ath:AT3G27630; -.
DR Araport; AT3G27630; -.
DR TAIR; locus:2089169; AT3G27630.
DR HOGENOM; CLU_2226943_0_0_1; -.
DR OMA; EKLICPP; -.
DR OrthoDB; 1582126at2759; -.
DR PhylomeDB; Q9LVX6; -.
DR PRO; PR:Q9LVX6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LVX6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:TAIR.
DR GO; GO:0045839; P:negative regulation of mitotic nuclear division; IBA:GO_Central.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IEA:InterPro.
DR InterPro; IPR040389; SMR.
DR PANTHER; PTHR33142; PTHR33142; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Protein kinase inhibitor; Reference proteome.
FT CHAIN 1..99
FT /note="Cyclin-dependent protein kinase inhibitor SMR7"
FT /id="PRO_0000438466"
FT REGION 49..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 99 AA; 11200 MW; D7AF7AD04A46091F CRC64;
MGISKKSQVS RELDTDGKKF IFAKTSIRAS LKPVKTKLIK PERESEDGIC ITPTARGAKT
PECPAAPRKR PPVLKCQNNI RIEYFVPPSD FELVFIQRR
