BIO5_YEAST
ID BIO5_YEAST Reviewed; 561 AA.
AC P53744; D6W1N1;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=7-keto 8-aminopelargonic acid transporter;
DE Short=KAPA transporter;
GN Name=BIO5; OrderedLocusNames=YNR056C; ORFNames=N3502;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=ATCC 28383 / FL100 / VTT C-80102;
RX PubMed=10333520; DOI=10.1016/s0378-1119(99)00117-1;
RA Phalip V., Kuhn I., Lemoine Y., Jeltsch J.-M.;
RT "Characterization of the biotin biosynthesis pathway in Saccharomyces
RT cerevisiae and evidence for a cluster containing BIO5, a novel gene
RT involved in vitamer uptake.";
RL Gene 232:43-51(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Transport into the cell of 7-keto 8-aminopelargonic acid.
CC {ECO:0000269|PubMed:10333520}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. {ECO:0000305}.
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DR EMBL; U90440; AAB50012.1; -; Genomic_DNA.
DR EMBL; Z71671; CAA96337.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10597.1; -; Genomic_DNA.
DR PIR; S63388; S63388.
DR RefSeq; NP_014454.3; NM_001183233.3.
DR AlphaFoldDB; P53744; -.
DR BioGRID; 35882; 44.
DR DIP; DIP-7726N; -.
DR IntAct; P53744; 2.
DR MINT; P53744; -.
DR STRING; 4932.YNR056C; -.
DR TCDB; 2.A.3.4.4; the amino acid-polyamine-organocation (apc) family.
DR CarbonylDB; P53744; -.
DR PaxDb; P53744; -.
DR TopDownProteomics; P53744; -.
DR EnsemblFungi; YNR056C_mRNA; YNR056C; YNR056C.
DR GeneID; 855793; -.
DR KEGG; sce:YNR056C; -.
DR SGD; S000005339; BIO5.
DR VEuPathDB; FungiDB:YNR056C; -.
DR eggNOG; KOG1289; Eukaryota.
DR HOGENOM; CLU_004495_2_3_1; -.
DR InParanoid; P53744; -.
DR OMA; VCNISAH; -.
DR BioCyc; YEAST:G3O-33362-MON; -.
DR PRO; PR:P53744; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P53744; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IDA:SGD.
DR GO; GO:0009102; P:biotin biosynthetic process; IMP:SGD.
DR GO; GO:0051180; P:vitamin transport; IDA:SGD.
DR InterPro; IPR002293; AA/rel_permease1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..561
FT /note="7-keto 8-aminopelargonic acid transporter"
FT /id="PRO_0000054282"
FT TOPO_DOM 1..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..77
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..230
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..281
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 343..369
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..439
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 461
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 483..507
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 529..540
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 541..560
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 561
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 561 AA; 62428 MW; 7FA5A64FA0D4250F CRC64;
MNRVGAVFLF VYERNFFLSI VPDRHRTEIR MSSSERSEVK FDKHFNWWSL LGIAFSLSCS
WVGISASMAV GIASGGPLLI IYGLIIAAFF SLMCGISLGD FAAILPNSSG GSFWVLKMLE
QESVTLKTPE YEDPSDDDEE VFLENYCQTF NVEVSSKFQK VSSMVVGLLN YFGAIFTTAS
ICSSLSMSCI GIHKLLHPDY ELKHWHVFVG YECINAVLTL FNIYSTPLPY ISQFGLYTSL
LSFAMTFIIC IVSRSDNTVD PWPKASNIFG SFDNQTGWNS SGMAFVVGLV NPIWAFVGID
SATHMIDEVG YSKSRFLVPK VIITTIIVGF VTSFIYCVGL FFCITDQTAV VESILPIVEI
FYQATGNRNL SVFLQCMCIT TGFVSGIASG TWQSRILQSF GKSYAPFYKE GSLGNKSLKK
LAVLTPGFKS PLYAHFLSQI CVTIIGCIFM GSSTAFNAII TACITLLLMS YAVPSFIFLF
VIKKEKFIHR IESDVNCVSR PNRRRMSMIP HIICILWTLF CLVFLSFPYT LPVTAGNMNY
TSVVYAVVFC IISIVVFPTC I
