ID   SMRP1_BOVIN             Reviewed;         304 AA.
AC   Q32KP0;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Spermatid-specific manchette-related protein 1;
DE   AltName: Full=Ciliated bronchial epithelial protein 1;
GN   Name=SMRP1; Synonyms=CBE1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in spermatogenesis. May be involved in
CC       differentiation or function of ciliated cells (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with alpha-tubulin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localizes to the manchette
CC       in elongating spermatids. Predominantly perinuclear in bronchial
CC       epithelial cells but also detected in the nucleus in some primary
CC       epithelial cells and in a number of cell lines (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMRP1 family. {ECO:0000305}.
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DR   EMBL; BC109997; AAI09998.1; -; mRNA.
DR   RefSeq; NP_001069708.1; NM_001076240.1.
DR   AlphaFoldDB; Q32KP0; -.
DR   STRING; 9913.ENSBTAP00000011027; -.
DR   PaxDb; Q32KP0; -.
DR   Ensembl; ENSBTAT00000011027; ENSBTAP00000011027; ENSBTAG00000008376.
DR   GeneID; 540767; -.
DR   KEGG; bta:540767; -.
DR   CTD; 540767; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008376; -.
DR   eggNOG; ENOG502QRFQ; Eukaryota.
DR   GeneTree; ENSGT00940000161008; -.
DR   HOGENOM; CLU_093197_0_0_1; -.
DR   InParanoid; Q32KP0; -.
DR   OrthoDB; 238940at2759; -.
DR   TreeFam; TF335656; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000008376; Expressed in semen and 106 other tissues.
DR   ExpressionAtlas; Q32KP0; baseline and differential.
DR   GO; GO:0002177; C:manchette; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0043014; F:alpha-tubulin binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR028195; SMRP1.
DR   PANTHER; PTHR35664; PTHR35664; 1.
DR   Pfam; PF15181; SMRP1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Differentiation; Nucleus; Reference proteome;
KW   Spermatogenesis.
FT   CHAIN           1..304
FT                   /note="Spermatid-specific manchette-related protein 1"
FT                   /id="PRO_0000296257"
SQ   SEQUENCE   304 AA;  35066 MW;  B2E7E48040E76C69 CRC64;
     MFLFSRKTKT PISTYSDSYR APTSIKEVYK DPPLWAWEAN KFVTPGLTHT AQRHVDPDAL
     QKMLKCAVQD YSYKGSIPSH PYFPEKYWLC PEEADRCNPN YLCGNPNYLC SNQYNTWRMG
     PYNCWNKCTT YLPRLPKEAG METVVRGMPL VYPPKPERLN AYEREVVVNM LNSLSRNQPL
     PQITPRCGCV DPLPGRLPFQ GYESACSGRH YCLRGMDYCV SGPPCTERRL RPLCTELPTV
     RSVSPCEHRS GMQCAVITPQ PSYYPCPNLR WDTSHFKKTG GSQRNNYVVH PEFVSETYPD
     YHCW