ID   SMRP1_MACFA             Reviewed;         262 AA.
AC   Q95LU0; G7PS37;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 2.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Spermatid-specific manchette-related protein 1;
DE   AltName: Full=Ciliated bronchial epithelial protein 1;
GN   Name=SMRP1; Synonyms=CBE1; ORFNames=EGM_06900, QtsA-18012;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- FUNCTION: May play a role in spermatogenesis. May be involved in
CC       differentiation or function of ciliated cells (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with alpha-tubulin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localizes to the manchette
CC       in elongating spermatids. Predominantly perinuclear in bronchial
CC       epithelial cells but also detected in the nucleus in some primary
CC       epithelial cells and in a number of cell lines (By similarity).
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q95LU0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q95LU0-2; Sequence=VSP_042862;
CC   -!- SIMILARITY: Belongs to the SMRP1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB64496.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB071102; BAB64496.1; ALT_TERM; mRNA.
DR   EMBL; CM001290; EHH57303.1; -; Genomic_DNA.
DR   RefSeq; XP_005581541.1; XM_005581484.1. [Q95LU0-1]
DR   AlphaFoldDB; Q95LU0; -.
DR   SMR; Q95LU0; -.
DR   STRING; 9541.XP_005581539.1; -.
DR   Ensembl; ENSMFAT00000013898; ENSMFAP00000039634; ENSMFAG00000046012. [Q95LU0-1]
DR   GeneID; 102115040; -.
DR   CTD; 102115040; -.
DR   VEuPathDB; HostDB:ENSMFAG00000046012; -.
DR   eggNOG; ENOG502QRFQ; Eukaryota.
DR   GeneTree; ENSGT00390000000945; -.
DR   OMA; ANKFVTR; -.
DR   Proteomes; UP000009130; Chromosome 15.
DR   Proteomes; UP000233100; Chromosome 15.
DR   Bgee; ENSMFAG00000046012; Expressed in cerebellum.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0002177; C:manchette; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0043014; F:alpha-tubulin binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR028195; SMRP1.
DR   PANTHER; PTHR35664; PTHR35664; 1.
DR   Pfam; PF15181; SMRP1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Cytoskeleton; Differentiation; Nucleus;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..262
FT                   /note="Spermatid-specific manchette-related protein 1"
FT                   /id="PRO_0000296259"
FT   VAR_SEQ         137..143
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12498619"
FT                   /id="VSP_042862"
FT   CONFLICT        68
FT                   /note="V -> I (in Ref. 1; BAB64496)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        164
FT                   /note="N -> S (in Ref. 1; BAB64496)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   262 AA;  29929 MW;  C6D6AFD971524376 CRC64;
     MFLFSRKTKT PISTYSDSYR APTSIKEVYK DPPLCAWEAN KFLTPGLTHT MEQHVDPEAL
     QKMAKCAVQD YTYRGPISGH PYLPEKYWLS QEEADKCSPN YLGSNRYNTW RMEPYNSSCC
     NKYTTYLPRL PKEAGMETAV RGMPLECPPK PERLNAYERE VMVNMLNSLS RNQQLPRITP
     RCGCVDPLPG RLPFHGYESA CSGRHYCLRG MDYYASGAPC TDRRLRPWCR ELPTLCTSLR
     APARNAVCCY NSPAVILPIS EP