ID   SMS1A_CARAU             Reviewed;         114 AA.
AC   Q9YGH5;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Somatostatin-1A;
DE   Contains:
DE     RecName: Full=Somatostatin-26;
DE   Contains:
DE     RecName: Full=Somatostatin-14;
DE   Flags: Precursor;
GN   Name=sst1a;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9827009; DOI=10.1016/s0742-8413(98)00025-5;
RA   Lin X.-W., Otto C.J., Peter R.E.;
RT   "Evolution of neuroendocrine peptide systems: gonadotropin-releasing
RT   hormone and somatostatin.";
RL   Comp. Biochem. Physiol. 119C:375-388(1998).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   EMBL; U40754; AAD09359.1; -; mRNA.
DR   AlphaFoldDB; Q9YGH5; -.
DR   Ensembl; ENSCART00000012333; ENSCARP00000011694; ENSCARG00000005397.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   PANTHER; PTHR10558; PTHR10558; 1.
DR   Pfam; PF03002; Somatostatin; 1.
DR   PIRSF; PIRSF001814; Somatostatin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..88
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033115"
FT   PEPTIDE         89..114
FT                   /note="Somatostatin-26"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033116"
FT   PEPTIDE         101..114
FT                   /note="Somatostatin-14"
FT                   /id="PRO_0000033117"
FT   DISULFID        103..114
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   114 AA;  12575 MW;  B5920015E2D272A4 CRC64;
     MLSTRIQCAL ALLSLALAVC SVSAAPTDAK LRQLLQRSLL NPAGKQELAR YTLADLLSEL
     VQAENEALEP EDLSRAVEKD EVRLELERAA GPMLAPRERK AGCKNFFWKT FTSC