ID   SMS1B_CARAU             Reviewed;         111 AA.
AC   Q9YGH3;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Somatostatin-1B;
DE   Contains:
DE     RecName: Full=[Pro12]-somatostatin-24;
DE   Contains:
DE     RecName: Full=[Pro2]-somatostatin-14;
DE   Flags: Precursor;
GN   Name=sst1b;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Otto C.J., Lin X.-W., Peter R.E.;
RT   "Molecular cloning of cDNA encoding [Pro2]somatostatin-14 in goldfish.";
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   EMBL; U72656; AAD09631.1; -; mRNA.
DR   AlphaFoldDB; Q9YGH3; -.
DR   Ensembl; ENSCART00000152746; ENSCARP00000135984; ENSCARG00000070369.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   PANTHER; PTHR10558; PTHR10558; 1.
DR   Pfam; PF03002; Somatostatin; 1.
DR   PIRSF; PIRSF001814; Somatostatin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..87
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033118"
FT   PEPTIDE         88..111
FT                   /note="[Pro12]-somatostatin-24"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033119"
FT   PEPTIDE         98..111
FT                   /note="[Pro2]-somatostatin-14"
FT                   /id="PRO_0000033120"
FT   DISULFID        100..111
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   111 AA;  12558 MW;  0E93479BA2B9F051 CRC64;
     MQLLSSLVSL LLVLYSVRAA AVLPVEERNP AQSRELSKER KELILKLISG LLDGVDNSVL
     DGEIAPVPFD AEEPLESRLE ERAVYNRLSQ LPQRDRKAPC KNFFWKTFTS C