ID   SMS1_AMICA              Reviewed;          26 AA.
AC   Q9PRZ6;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Somatostatin-1;
DE   AltName: Full=Somatostatin I;
DE   Contains:
DE     RecName: Full=Somatostatin-26;
DE   Contains:
DE     RecName: Full=Somatostatin-14;
DE   Flags: Precursor; Fragment;
GN   Name=sst1;
OS   Amia calva (Bowfin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Amiiformes; Amiidae; Amia.
OX   NCBI_TaxID=7924;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=8105513; DOI=10.1016/0167-0115(93)90270-i;
RA   Wang Y., Youson J.H., Conlon J.M.;
RT   "Prosomatostatin-I is processed to somatostatin-26 and somatostatin-14 in
RT   the pancreas of the bowfin, Amia calva.";
RL   Regul. Pept. 47:33-39(1993).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   AlphaFoldDB; Q9PRZ6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   Pfam; PF03002; Somatostatin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Secreted.
FT   PEPTIDE         1..26
FT                   /note="Somatostatin-26"
FT                   /id="PRO_0000033113"
FT   PEPTIDE         13..26
FT                   /note="Somatostatin-14"
FT                   /id="PRO_0000033114"
FT   DISULFID        15..26
FT   NON_TER         1
SQ   SEQUENCE   26 AA;  2931 MW;  8A296DC3710552FE CRC64;
     SANPALAPRE RKAGCKNFFW KTFTSC