ID   SMS1_LOPAM              Reviewed;         121 AA.
AC   P01169;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Somatostatin-1;
DE   AltName: Full=Somatostatin I;
DE   Contains:
DE     RecName: Full=Somatostatin-14;
DE   Flags: Precursor;
GN   Name=sst1;
OS   Lophius americanus (American angler) (Anglerfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Lophiiformes; Lophiidae; Lophius.
OX   NCBI_TaxID=8073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6107860; DOI=10.1038/288137a0;
RA   Hobart P.M., Crawford R., Shen L., Pictet R., Rutter W.J.;
RT   "Cloning and sequence analysis of cDNAs encoding two distinct somatostatin
RT   precursors found in the endocrine pancreas of anglerfish.";
RL   Nature 288:137-141(1980).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 2-121.
RX   PubMed=6108560; DOI=10.1073/pnas.77.10.5869;
RA   Goodman R.H., Jacobs J.W., Chin W.W., Lund P.K., Dee P.C., Habener J.F.;
RT   "Nucleotide sequence of a cloned structural gene coding for a precursor of
RT   pancreatic somatostatin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:5869-5873(1980).
RN   [3]
RP   ERRATUM OF PUBMED:6108560.
RA   Goodman R.H., Jacobs J.W., Chin W.W., Lund P.K., Dee P.C., Habener J.F.;
RL   Proc. Natl. Acad. Sci. U.S.A. 79:1682-1682(1982).
RN   [4]
RP   PROTEIN SEQUENCE OF 108-121.
RX   PubMed=387385; DOI=10.1210/endo-105-6-1410;
RA   Noe B.D., Spiess J., Rivier J.E., Vale W.;
RT   "Isolation and characterization of somatostatin from anglerfish pancreatic
RT   islet.";
RL   Endocrinology 105:1410-1415(1979).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   EMBL; V00640; CAA23986.1; -; mRNA.
DR   PIR; A93236; RIAFSI.
DR   AlphaFoldDB; P01169; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   PANTHER; PTHR10558; PTHR10558; 1.
DR   Pfam; PF03002; Somatostatin; 1.
DR   PIRSF; PIRSF001814; Somatostatin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000305"
FT   PROPEP          25..105
FT                   /id="PRO_0000033130"
FT   PEPTIDE         108..121
FT                   /note="Somatostatin-14"
FT                   /id="PRO_0000033131"
FT   REGION          76..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        110..121
FT   CONFLICT        21
FT                   /note="A -> V (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        83
FT                   /note="G -> E (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   121 AA;  13325 MW;  D70C53DC798C2095 CRC64;
     MKMVSSSRLR CLLVLLLSLT ASISCSFAGQ RDSKLRLLLH RYPLQGSKQD MTRSALAELL
     LSDLLQGENE ALEEENFPLA EGGPEDAHAD LERAASGGPL LAPRERKAGC KNFFWKTFTS
     C