ID   SMS1_PROAN              Reviewed;         115 AA.
AC   Q9W7F0;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Somatostatin-1;
DE   AltName: Full=PSS1;
DE   AltName: Full=Somatostatin I;
DE   Contains:
DE     RecName: Full=Somatostatin-27;
DE   Contains:
DE     RecName: Full=Somatostatin-14;
DE   Flags: Precursor;
GN   Name=sst1;
OS   Protopterus annectens (African lungfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Dipnomorpha; Ceratodontiformes; Lepidosirenoidei; Protopteridae;
OC   Protopterus.
OX   NCBI_TaxID=7888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=10398054;
RX   DOI=10.1002/(sici)1096-9861(19990809)410:4<643::aid-cne10>3.0.co;2-#;
RA   Trabucchi M., Tostivint H., Lihrmann I., Jegou S., Vallarino M., Vaudry H.;
RT   "Molecular cloning of the cDNAs and distribution of the mRNAs encoding two
RT   somatostatin precursors in the African lungfish Protopterus annectens.";
RL   J. Comp. Neurol. 410:643-652(1999).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   EMBL; AF126243; AAD39138.1; -; mRNA.
DR   AlphaFoldDB; Q9W7F0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   PANTHER; PTHR10558; PTHR10558; 1.
DR   Pfam; PF03002; Somatostatin; 1.
DR   PIRSF; PIRSF001814; Somatostatin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..88
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033148"
FT   PEPTIDE         89..115
FT                   /note="Somatostatin-27"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033149"
FT   PEPTIDE         102..115
FT                   /note="Somatostatin-14"
FT                   /id="PRO_0000033150"
FT   REGION          65..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        104..115
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   115 AA;  12600 MW;  B0CEF1E603FEAF09 CRC64;
     MLSCRFQCAL VLLSLAVVFS KVSAAPSDLR LRQLLQRSLA AAAGKQELTK YSLAELLSEL
     AQSENDALDS SDLSRGADQD EVRLELDRSA NSSPLAARER KAGCKNFFWK TFTSC