ID   SMS2_CARAU              Reviewed;         120 AA.
AC   Q9YGH4; Q9PTU2;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Somatostatin-2;
DE   AltName: Full=Somatostatin II;
DE   Contains:
DE     RecName: Full=[Tyr21,Gly24]-somatostatin-28;
DE   Contains:
DE     RecName: Full=[Tyr7,Gly10]-somatostatin-14;
DE   Flags: Precursor;
GN   Name=sst2;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=9827009; DOI=10.1016/s0742-8413(98)00025-5;
RA   Lin X.-W., Otto C.J., Peter R.E.;
RT   "Evolution of neuroendocrine peptide systems: gonadotropin-releasing
RT   hormone and somatostatin.";
RL   Comp. Biochem. Physiol. 119C:375-388(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver;
RA   Otto C.J., Peter R.E.;
RT   "The expression of SRIF mRNA in the brain of goldfish.";
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   EMBL; U60262; AAD09626.1; -; mRNA.
DR   EMBL; AF025686; AAF15306.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9YGH4; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   PANTHER; PTHR10558; PTHR10558; 1.
DR   Pfam; PF03002; Somatostatin; 1.
DR   PIRSF; PIRSF001814; Somatostatin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..92
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033121"
FT   PEPTIDE         93..120
FT                   /note="[Tyr21,Gly24]-somatostatin-28"
FT                   /id="PRO_0000033122"
FT   PEPTIDE         107..120
FT                   /note="[Tyr7,Gly10]-somatostatin-14"
FT                   /id="PRO_0000033123"
FT   REGION          76..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..92
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        109..120
FT                   /evidence="ECO:0000250"
FT   CONFLICT        51
FT                   /note="Q -> RW (in Ref. 2; AAF15306)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   120 AA;  13723 MW;  98957D68011A651A CRC64;
     MRLCELHCYL ALLGLSLVLC GRCANSQLEP DLDFRHHRLL QRASATGQAT QDFTKRDVEK
     LLSLLSIPEM EMREKGLSMA GESEDLRLEQ ERSAESSNQL PTRVRKEGCK NFYWKGFTSC