ID   SMS2_MYOSC              Reviewed;          74 AA.
AC   P09876;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Somatostatin-2;
DE   AltName: Full=Somatostatin II;
DE   Contains:
DE     RecName: Full=[Tyr21,Gly24]-somatostatin-28;
DE   Contains:
DE     RecName: Full=[Tyr7,Gly10]-somatostatin-14;
DE   Flags: Precursor; Fragments;
GN   Name=sst2;
OS   Myoxocephalus scorpius (Shorthorn sculpin) (Cottus scorpius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Cottales; Cottidae; Myoxocephalus.
OX   NCBI_TaxID=8097;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=2889597; DOI=10.1111/j.1432-1033.1987.tb13465.x;
RA   Conlon J.M., Davis M.S., Falkmer S., Thim L.;
RT   "Structural characterization of peptides derived from prosomatostatins I
RT   and II isolated from the pancreatic islets of two species of teleostean
RT   fish: the daddy sculpin and the flounder.";
RL   Eur. J. Biochem. 168:647-652(1987).
RN   [2]
RP   PROTEIN SEQUENCE OF 47-74.
RC   TISSUE=Pancreas;
RX   PubMed=2883025; DOI=10.1016/0014-5793(87)80012-1;
RA   Cutfield S.M., Carne A., Cutfield J.F.;
RT   "The amino-acid sequences of sculpin islet somatostatin-28 and peptide
RT   YY.";
RL   FEBS Lett. 214:57-61(1987).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; S00166; S00166.
DR   AlphaFoldDB; P09876; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   PANTHER; PTHR10558; PTHR10558; 1.
DR   Pfam; PF03002; Somatostatin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Secreted.
FT   PROPEP          <1..46
FT                   /evidence="ECO:0000269|PubMed:2883025"
FT                   /id="PRO_0000045871"
FT   PEPTIDE         47..74
FT                   /note="[Tyr21,Gly24]-somatostatin-28"
FT                   /id="PRO_0000033135"
FT   PEPTIDE         61..74
FT                   /note="[Tyr7,Gly10]-somatostatin-14"
FT                   /id="PRO_0000033136"
FT   DISULFID        63..74
FT                   /evidence="ECO:0000269|PubMed:2883025"
FT   NON_CONS        12..13
FT                   /evidence="ECO:0000305"
FT   NON_CONS        46..47
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   74 AA;  8036 MW;  6864A59A3FA72C47 CRC64;
     ARGAGLLSQD WSAVEDLLAQ MSLPEADAQR EAEVVSVATG GRLNLESVDP PNNIPLRERK
     AGCKNFYWKG FTSC