ID   SMS2_ONCMY              Reviewed;         115 AA.
AC   Q91194;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Somatostatin-2;
DE   AltName: Full=Somatostatin II;
DE   Contains:
DE     RecName: Full=[Tyr21,Gly24]-somatostatin-28;
DE   Contains:
DE     RecName: Full=[Tyr7,Gly10]-somatostatin-14;
DE   Flags: Precursor;
GN   Name=sst2;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7628684; DOI=10.1006/gcen.1995.1067;
RA   Moore C.A., Kittilson J.D., Dahl S.K., Sheridan M.A.;
RT   "Isolation and characterization of a cDNA encoding for preprosomatostatin
RT   containing [Tyr7, Gly10]-somatostatin-14 from the endocrine pancreas of
RT   rainbow trout, Oncorhynchus mykiss.";
RL   Gen. Comp. Endocrinol. 98:253-261(1995).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   EMBL; U32471; AAC59695.1; -; mRNA.
DR   PIR; I51064; I51064.
DR   RefSeq; NP_001118175.1; NM_001124703.1.
DR   AlphaFoldDB; Q91194; -.
DR   GeneID; 100136751; -.
DR   KEGG; omy:100136751; -.
DR   OrthoDB; 1561305at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0031877; F:somatostatin receptor binding; IDA:AgBase.
DR   GO; GO:0031878; F:type 1 somatostatin receptor binding; IPI:AgBase.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   PANTHER; PTHR10558; PTHR10558; 1.
DR   Pfam; PF03002; Somatostatin; 1.
DR   PIRSF; PIRSF001814; Somatostatin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..87
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033139"
FT   PEPTIDE         88..115
FT                   /note="[Tyr21,Gly24]-somatostatin-28"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033140"
FT   PEPTIDE         102..115
FT                   /note="[Tyr7,Gly10]-somatostatin-14"
FT                   /id="PRO_0000033141"
FT   DISULFID        104..115
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   115 AA;  12963 MW;  520595025FCA6D91 CRC64;
     MKVCRIHCAL ALLGLALAIC SQGAASQPDL DLRSRRLLQR ARAAAWPHRS GVSERWRTFY
     PNCPCLRPRK VKCPAGAKED LRVELERSVG NPNNLPPRER KAGCKNFYWK GFTSC