ID   SMS2_ORENI              Reviewed;          28 AA.
AC   P81029;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Somatostatin-2;
DE   AltName: Full=Somatostatin II;
DE   Contains:
DE     RecName: Full=[Tyr21,Gly24]-somatostatin-28;
DE   Contains:
DE     RecName: Full=[Tyr7,Gly10]-somatostatin-14;
DE   Flags: Precursor; Fragment;
GN   Name=sst2;
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7656183; DOI=10.1016/0742-8413(95)00023-z;
RA   Nguyen T.M., Wright J.R. Jr., Nielsen P.F., Conlon J.M.;
RT   "Characterization of the pancreatic hormones from the Brockmann body of the
RT   tilapia: implications for islet xenograft studies.";
RL   Comp. Biochem. Physiol. 111C:33-44(1995).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   AlphaFoldDB; P81029; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   Pfam; PF03002; Somatostatin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Reference proteome; Secreted.
FT   PEPTIDE         1..28
FT                   /note="[Tyr21,Gly24]-somatostatin-28"
FT                   /id="PRO_0000033142"
FT   PEPTIDE         15..28
FT                   /note="[Tyr7,Gly10]-somatostatin-14"
FT                   /id="PRO_0000033143"
FT   DISULFID        17..28
FT   NON_TER         1
SQ   SEQUENCE   28 AA;  3155 MW;  47C049F4866EF4AC CRC64;
     SADQPNSIPP RERKAGCKNF YWKGLTSC