ID   SMS2_PELRI              Reviewed;         103 AA.
AC   P87385;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Somatostatin-2;
DE   AltName: Full=PSS2;
DE   Contains:
DE     RecName: Full=[Pro2,Met13]-somatostatin-14;
DE     AltName: Full=Somatostatin-2;
DE              Short=S-2;
DE              Short=SS2;
DE   Flags: Precursor;
GN   Name=sst2;
OS   Pelophylax ridibundus (Marsh frog) (Rana ridibunda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=8406;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8901629; DOI=10.1073/pnas.93.22.12605;
RA   Tostivint H., Lihrmann I., Bucharles C., Vieau D., Coulouarn Y.,
RA   Fournier A., Conlon J.M., Vaudry H.;
RT   "Occurrence of two somatostatin variants in the frog brain:
RT   characterization of the cDNAs, distribution of the mRNAs, and receptor-
RT   binding affinities of the peptides.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:12605-12610(1996).
RN   [2]
RP   PROTEIN SEQUENCE OF 90-103.
RC   TISSUE=Brain;
RX   PubMed=1358069; DOI=10.1016/0006-291x(92)92409-q;
RA   Vaudry H., Chartrel N., Conlon J.M.;
RT   "Isolation of [Pro2,Met13]somatostatin-14 and somatostatin-14 from the frog
RT   brain reveals the existence of a somatostatin gene family in a tetrapod.";
RL   Biochem. Biophys. Res. Commun. 188:477-482(1992).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   EMBL; U68137; AAC60094.1; -; mRNA.
DR   PIR; JC6167; JC6167.
DR   AlphaFoldDB; P87385; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   Pfam; PF03002; Somatostatin; 1.
DR   PIRSF; PIRSF001814; Somatostatin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   PROPEP          22..87
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000033111"
FT   PEPTIDE         90..103
FT                   /note="[Pro2,Met13]-somatostatin-14"
FT                   /id="PRO_0000033112"
FT   DISULFID        92..103
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   103 AA;  11648 MW;  ADBA7329857EF77A CRC64;
     MLGSAGTLLL LLLAWGARAL SQPDDNRITT GRNQDLNAIQ QDLLLKLLSG WTDSRESNLV
     EVERNVPDPP EPKIPPSVKF PRLSLRERKA PCKNFFWKTF TMC