ID   SMS2_PLAFE              Reviewed;          73 AA.
AC   P21780;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Somatostatin-2;
DE   AltName: Full=Somatostatin II;
DE   Contains:
DE     RecName: Full=[Tyr21,Gly24]-somatostatin-28;
DE   Contains:
DE     RecName: Full=[Tyr7,Gly10]-somatostatin-14;
DE   Flags: Precursor; Fragments;
GN   Name=sst2;
OS   Platichthys flesus (European flounder) (Pleuronectes flesus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae;
OC   Platichthys.
OX   NCBI_TaxID=8260;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=2889597; DOI=10.1111/j.1432-1033.1987.tb13465.x;
RA   Conlon J.M., Davis M.S., Falkmer S., Thim L.;
RT   "Structural characterization of peptides derived from prosomatostatins I
RT   and II isolated from the pancreatic islets of two species of teleostean
RT   fish: the daddy sculpin and the flounder.";
RL   Eur. J. Biochem. 168:647-652(1987).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   PIR; S00169; S00169.
DR   AlphaFoldDB; P21780; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   PANTHER; PTHR10558; PTHR10558; 1.
DR   Pfam; PF03002; Somatostatin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Secreted.
FT   PROPEP          <1..45
FT                   /id="PRO_0000045873"
FT   PEPTIDE         46..73
FT                   /note="[Tyr21,Gly24]-somatostatin-28"
FT                   /evidence="ECO:0000269|PubMed:2889597"
FT                   /id="PRO_0000033146"
FT   PEPTIDE         60..73
FT                   /note="[Tyr7,Gly10]-somatostatin-14"
FT                   /id="PRO_0000033147"
FT   REGION          23..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        62..73
FT   NON_CONS        10..11
FT                   /evidence="ECO:0000305"
FT   NON_CONS        45..46
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   73 AA;  7989 MW;  CCCBA6B30DCB29BB CRC64;
     SAGLLTQEWS AVEDLLAQMS LPEADAQRDA EMVSTATGGG RMNQESIEPP NNLPPRERKA
     GCKNFYWKGF TSC