ID   SMSR1_CAEEL             Reviewed;         483 AA.
AC   Q20696;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Sphingomyelin synthase-related 1;
DE            EC=2.7.8.-;
GN   ORFNames=F53B1.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=14685263; DOI=10.1038/sj.emboj.7600034;
RA   Huitema K., Van Den Dikkenberg J., Brouwers J.F.H.M., Holthuis J.C.;
RT   "Identification of a family of animal sphingomyelin synthases.";
RL   EMBO J. 23:33-44(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC       {ECO:0000305}.
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DR   EMBL; FO081052; CCD68826.1; -; Genomic_DNA.
DR   PIR; T16443; T16443.
DR   RefSeq; NP_508389.1; NM_075988.5.
DR   AlphaFoldDB; Q20696; -.
DR   SMR; Q20696; -.
DR   STRING; 6239.F53B1.2; -.
DR   EPD; Q20696; -.
DR   PaxDb; Q20696; -.
DR   PeptideAtlas; Q20696; -.
DR   EnsemblMetazoa; F53B1.2.1; F53B1.2.1; WBGene00018735.
DR   GeneID; 180524; -.
DR   KEGG; cel:CELE_F53B1.2; -.
DR   UCSC; F53B1.2; c. elegans.
DR   CTD; 180524; -.
DR   WormBase; F53B1.2; CE04642; WBGene00018735; -.
DR   eggNOG; KOG3058; Eukaryota.
DR   GeneTree; ENSGT00940000155540; -.
DR   HOGENOM; CLU_027104_1_0_1; -.
DR   InParanoid; Q20696; -.
DR   OMA; WKTVLSC; -.
DR   OrthoDB; 599210at2759; -.
DR   PhylomeDB; Q20696; -.
DR   Reactome; R-CEL-1660661; Sphingolipid de novo biosynthesis.
DR   PRO; PR:Q20696; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00018735; Expressed in embryo and 4 other tissues.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0047493; F:ceramide cholinephosphotransferase activity; IBA:GO_Central.
DR   GO; GO:0033188; F:sphingomyelin synthase activity; IBA:GO_Central.
DR   GO; GO:0046513; P:ceramide biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006686; P:sphingomyelin biosynthetic process; NAS:UniProtKB.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR045221; Sphingomyelin_synth-like.
DR   InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR   PANTHER; PTHR21290; PTHR21290; 1.
DR   Pfam; PF14360; PAP2_C; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Membrane; Reference proteome; Sphingolipid metabolism;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..483
FT                   /note="Sphingomyelin synthase-related 1"
FT                   /id="PRO_0000221077"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        397..483
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          450..483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..474
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        330
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        373
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        377
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   483 AA;  54988 MW;  41828EA82305FB6C CRC64;
     MLDNRPIPAD PNEWRCEDVG NWLKKIGMAK YADLIAMKHK VDGKCLLALT DTDLKDPPVS
     INCLGDIKKI LFAIEFLSQK VVEIGNSGVH HRSTPNGNGP SLKNSKDGLL VEYNEQNHLS
     ISGEDVYTTT RRAEIVEDEE TLLDTLAKSS DGTSTVQLIS REEIIRQVER PDTYFKSVAK
     LLIAFAYSSL SFLMTSFVMV LVHDRVPDTK TYPPLPDIVL DNVPHIPWAF DMCETIGLVL
     AVVWFTVLFF HNQRVIVARR MFSLLGTVFL LRCFTMLITS LSVPGIHLQC EARPNTTMQE
     KLHKAFHIWS NLGMSLHGVR SCGDYMFSGH TTVITMISHF ITEYTPADWT GLHTFTWVLN
     CFAIFLILAA HEHYSIDVFI AFYISSRMFL YYHAYAYNHA GITATDYRMR TWFPLGWFFE
     YGSQGKVENE FSLPINIRIP RRVFFAKSEE PKITPKSDSS RKRSSVVAAK QNGNSKNHTK
     KHN