ID   SMSR2_CAEEL             Reviewed;         327 AA.
AC   Q9TYV2; U4PB50; U4PED8;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-APR-2018, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Sphingomyelin synthase-related 2;
DE            EC=2.7.8.-;
GN   Name=sms-5 {ECO:0000312|WormBase:W07E6.3b};
GN   ORFNames=W07E6.3 {ECO:0000312|WormBase:W07E6.3b};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=14685263; DOI=10.1038/sj.emboj.7600034;
RA   Huitema K., Van Den Dikkenberg J., Brouwers J.F.H.M., Holthuis J.C.;
RT   "Identification of a family of animal sphingomyelin synthases.";
RL   EMBO J. 23:33-44(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b {ECO:0000312|WormBase:W07E6.3b};
CC         IsoId=Q9TYV2-1; Sequence=Displayed;
CC       Name=c {ECO:0000312|WormBase:W07E6.3c};
CC         IsoId=Q9TYV2-3; Sequence=VSP_059558;
CC   -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284602; CDH93085.1; -; Genomic_DNA.
DR   EMBL; BX284602; CDH93086.1; -; Genomic_DNA.
DR   PIR; T33807; T33807.
DR   RefSeq; NP_001293556.1; NM_001306627.1. [Q9TYV2-1]
DR   RefSeq; NP_001293557.1; NM_001306628.1. [Q9TYV2-3]
DR   AlphaFoldDB; Q9TYV2; -.
DR   STRING; 6239.W07E6.3a; -.
DR   PaxDb; Q9TYV2; -.
DR   EnsemblMetazoa; W07E6.3b.1; W07E6.3b.1; WBGene00021075. [Q9TYV2-1]
DR   EnsemblMetazoa; W07E6.3c.1; W07E6.3c.1; WBGene00021075. [Q9TYV2-3]
DR   GeneID; 189276; -.
DR   KEGG; cel:CELE_W07E6.3; -.
DR   UCSC; W07E6.3; c. elegans. [Q9TYV2-1]
DR   CTD; 189276; -.
DR   WormBase; W07E6.3b; CE49035; WBGene00021075; sms-5. [Q9TYV2-1]
DR   WormBase; W07E6.3c; CE48509; WBGene00021075; sms-5. [Q9TYV2-3]
DR   eggNOG; KOG3058; Eukaryota.
DR   HOGENOM; CLU_027104_0_2_1; -.
DR   InParanoid; Q9TYV2; -.
DR   OrthoDB; 599210at2759; -.
DR   PhylomeDB; Q9TYV2; -.
DR   Reactome; R-CEL-1660661; Sphingolipid de novo biosynthesis.
DR   PRO; PR:Q9TYV2; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00021075; Expressed in larva and 3 other tissues.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0047493; F:ceramide cholinephosphotransferase activity; IBA:GO_Central.
DR   GO; GO:0033188; F:sphingomyelin synthase activity; IBA:GO_Central.
DR   GO; GO:0046513; P:ceramide biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006686; P:sphingomyelin biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR045221; Sphingomyelin_synth-like.
DR   InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR   PANTHER; PTHR21290; PTHR21290; 1.
DR   Pfam; PF14360; PAP2_C; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Lipid metabolism; Membrane; Reference proteome;
KW   Sphingolipid metabolism; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..327
FT                   /note="Sphingomyelin synthase-related 2"
FT                   /id="PRO_0000221078"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..327
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        201
FT                   /evidence="ECO:0000250|UniProtKB:Q8NHU3"
FT   ACT_SITE        244
FT                   /evidence="ECO:0000250|UniProtKB:Q8NHU3"
FT   ACT_SITE        248
FT                   /evidence="ECO:0000250|UniProtKB:Q8NHU3"
FT   VAR_SEQ         1..106
FT                   /note="Missing (in isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_059558"
SQ   SEQUENCE   327 AA;  37849 MW;  05FEAEABFE0371E4 CRC64;
     MKKDAENENL LHAYEHDEQS SKYFIKPDSR YSIDDDISVK IDGKQLEVRK WPTLLATAMV
     GVGWLSNEVA LAWVHERVPD DYHPLPDLFF SHFPEIRGAI RIAEYIMMIL LISALLVMFT
     HQHRWIVIRR VFFCIAMAYS FRALCVTIFQ VPVPSINTYC APKSNSSLEL VAGRVVKMFW
     SAGIEQLRPR ELCGDLIVSG HTLTIFTAFL VFKTYAPQRL QPLSHIYHVL AFTALFSILL
     ARKHYMIDIV LGYTVSTRIF MEYHALAASY HNRTFETNPL AWSFWSFFIP IFECDAPANM
     HNHLLLYNRS TSSKNVSTLK KSRRSFE