ID   SMST_SANMU              Reviewed;         562 AA.
AC   F6M8H7;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=Probable sesquiterpene synthase;
DE            Short=SmSTPS;
DE            EC=4.2.3.-;
GN   Name=STPS;
OS   Santalum murrayanum (Bitter quandong).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Santalales; Santalaceae; Santalum.
OX   NCBI_TaxID=453085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=21454632; DOI=10.1074/jbc.m111.231787;
RA   Jones C.G., Moniodis J., Zulak K.G., Scaffidi A., Plummer J.A.,
RA   Ghisalberti E.L., Barbour E.L., Bohlmann J.;
RT   "Sandalwood fragrance biosynthesis involves sesquiterpene synthases of both
RT   the terpene synthase (TPS)-a and TPS-b Subfamilies, including santalene
RT   synthases.";
RL   J. Biol. Chem. 286:17445-17454(2011).
CC   -!- FUNCTION: Sesquiterpene synthase. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC       Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. {ECO:0000250};
CC   -!- MISCELLANEOUS: The oil-deficient phenotype of this species is not due
CC       to the absence of the genes encoding enzymes for santalene
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the terpene synthase family. Tpsa subfamily.
CC       {ECO:0000305}.
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DR   EMBL; JF746810; AEF32537.1; -; Genomic_DNA.
DR   AlphaFoldDB; F6M8H7; -.
DR   SMR; F6M8H7; -.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0010333; F:terpene synthase activity; IEA:InterPro.
DR   GO; GO:0016102; P:diterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd00684; Terpene_cyclase_plant_C1; 1.
DR   Gene3D; 1.10.600.10; -; 1.
DR   Gene3D; 1.50.10.130; -; 1.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR034741; Terpene_cyclase-like_1_C.
DR   InterPro; IPR044814; Terpene_cyclase_plant_C1.
DR   InterPro; IPR001906; Terpene_synth_N.
DR   InterPro; IPR036965; Terpene_synth_N_sf.
DR   InterPro; IPR005630; Terpene_synthase_metal-bd.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF01397; Terpene_synth; 1.
DR   Pfam; PF03936; Terpene_synth_C; 1.
DR   SFLD; SFLDG01019; Terpene_Cyclase_Like_1_C_Termi; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
DR   SUPFAM; SSF48576; SSF48576; 1.
PE   3: Inferred from homology;
KW   Lyase; Magnesium; Manganese; Metal-binding.
FT   CHAIN           1..562
FT                   /note="Probable sesquiterpene synthase"
FT                   /id="PRO_0000419328"
FT   MOTIF           315..319
FT                   /note="DDXXD motif"
FT   BINDING         315
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         315
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         319
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         319
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         467
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   562 AA;  65838 MW;  B1121B014DE771E8 CRC64;
     MENQKMPISS VPNLKDLNMI SRPIANFPPS IWGDRFINYT CEDENDQTQK ERQVEELKEQ
     VRRELAATVD KPLQQLNIID ATQRLGIAYL FENEIEESLK HIYLHTYVEN NCFEGSDDLY
     SVALWFRLLR QNGYKVSCDV FNKFRDNEGN FKNNLMEDAK GLLELYEATH VSIHGEEMLD
     DALEFTKTRL ESVVSHLNYP LAEQVRHALY QPLHRGLPRL EAVYFFRIYE AHASHNKALL
     KLAKLDFNLL QSFHKKELSD IARWWKSLDF AAKFPFARDR LVEGYFWVLG VYFEPQYSLA
     RKIIIKVFTM ISTIDDIYDA YGTLDELKLF TKAMQRWDVG SLDQLPEYMK PCYKSILDVY
     NEIEEEMANQ GSLFRMHYAK EVMKTIVEGY MDEAKWCHEK YVPTFQEYMS VALVTSGYTF
     LTTISYLGMG EIASKEAFDW LFSHPPVIEA SESVGRLMDD MRSHKFEQER GHVASGIECY
     MKQYGVTEEE AHDEFRKRLV KAWKDINEEC LRPYRVPKPL LTRILNLTRV IDVIYKNEDG
     YTHVKKAMKD NIASLLIDPV IV