ID   SMS_CHICK               Reviewed;         116 AA.
AC   P33094;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Somatostatin;
DE   Contains:
DE     RecName: Full=Somatostatin-28;
DE   Contains:
DE     RecName: Full=Somatostatin-14;
DE   Flags: Precursor;
GN   Name=SST;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pancreas;
RA   Nata K., Kobayashi T., Karahashi K., Kato S., Yamamoto H., Yonekura H.,
RA   Okamoto H.;
RT   "Nucleotide sequence determination of chicken somatostatin precursor
RT   cDNA.";
RL   Submitted (JUN-1991) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   EMBL; X60191; CAA42747.1; -; mRNA.
DR   PIR; S20630; S20630.
DR   RefSeq; NP_990667.1; NM_205336.1.
DR   AlphaFoldDB; P33094; -.
DR   STRING; 9031.ENSGALP00000011889; -.
DR   Ensembl; ENSGALT00000011903; ENSGALP00000011889; ENSGALG00000007361.
DR   GeneID; 396279; -.
DR   KEGG; gga:396279; -.
DR   CTD; 112256; -.
DR   VEuPathDB; HostDB:geneid_396279; -.
DR   eggNOG; ENOG502S11K; Eukaryota.
DR   GeneTree; ENSGT00510000047914; -.
DR   HOGENOM; CLU_124515_1_1_1; -.
DR   InParanoid; P33094; -.
DR   OMA; PDEMRME; -.
DR   OrthoDB; 1561305at2759; -.
DR   PhylomeDB; P33094; -.
DR   Reactome; R-GGA-375276; Peptide ligand-binding receptors.
DR   Reactome; R-GGA-418594; G alpha (i) signalling events.
DR   PRO; PR:P33094; -.
DR   Proteomes; UP000000539; Chromosome 9.
DR   Bgee; ENSGALG00000007361; Expressed in brain and 2 other tissues.
DR   ExpressionAtlas; P33094; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   PANTHER; PTHR10558; PTHR10558; 1.
DR   Pfam; PF03002; Somatostatin; 1.
DR   PIRSF; PIRSF001814; Somatostatin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   PROPEP          25..88
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000033106"
FT   PEPTIDE         89..116
FT                   /note="Somatostatin-28"
FT                   /id="PRO_0000033107"
FT   PEPTIDE         103..116
FT                   /note="Somatostatin-14"
FT                   /id="PRO_0000033108"
FT   REGION          60..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..82
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        105..116
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   116 AA;  12675 MW;  8A5BB9BDA8A291BA CRC64;
     MLSCRLQCAL ALLSIALAVG TVSAAPSDPR LRQFLQKSLA AAAGKQELAK YFLAELLSEP
     SQTENEALES EDLSRGAEQD EVRLELERSA NSNPALAPRE RKAGCKNFFW KTFTSC