ID   SMS_LAMFL               Reviewed;          35 AA.
AC   Q9PRR0;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Somatostatin;
DE   Contains:
DE     RecName: Full=Somatostatin-35;
DE   Contains:
DE     RecName: Full=Somatostatin-14;
DE   Flags: Precursor; Fragment;
GN   Name=sst;
OS   Lampetra fluviatilis (European river lamprey) (Petromyzon fluviatilis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Lampetra.
OX   NCBI_TaxID=7748;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=8575665; DOI=10.1006/gcen.1995.1138;
RA   Conlon J.M., Bondareva V., Rusakov Y., Plisetskaya E.M., Mynarcik D.C.,
RA   Whittaker J.;
RT   "Characterization of insulin, glucagon, and somatostatin from the river
RT   lamprey, Lampetra fluviatilis.";
RL   Gen. Comp. Endocrinol. 100:96-105(1995).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   AlphaFoldDB; Q9PRR0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   Pfam; PF03002; Somatostatin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Secreted.
FT   PEPTIDE         1..35
FT                   /note="Somatostatin-35"
FT                   /id="PRO_0000033128"
FT   PEPTIDE         22..35
FT                   /note="Somatostatin-14"
FT                   /id="PRO_0000033129"
FT   DISULFID        24..35
FT   NON_TER         1
SQ   SEQUENCE   35 AA;  3584 MW;  B6637C6E6A8F5AEE CRC64;
     AAAAPGAAGG AQLPLGNRER KAGCKNFFWK TFSSC