ID   SMS_MYXGL               Reviewed;          34 AA.
AC   P19209;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Somatostatin;
DE   Contains:
DE     RecName: Full=Somatostatin-34;
DE   Contains:
DE     RecName: Full=Somatostatin-14;
DE   Flags: Precursor; Fragment;
GN   Name=sst;
OS   Myxine glutinosa (Atlantic hagfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC   Myxiniformes; Myxinidae; Myxininae; Myxine.
OX   NCBI_TaxID=7769;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2896118; DOI=10.1210/endo-122-5-1855;
RA   Conlon J.M., Askensten U., Falkmer S., Thim L.;
RT   "Primary structures of somatostatins from the islet organ of the hagfish
RT   suggest an anomalous pathway of posttranslational processing of
RT   prosomatostatin-1.";
RL   Endocrinology 122:1855-1859(1988).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   PIR; A32271; A32271.
DR   AlphaFoldDB; P19209; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   Pfam; PF03002; Somatostatin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Secreted.
FT   PEPTIDE         1..34
FT                   /note="Somatostatin-34"
FT                   /id="PRO_0000033137"
FT   PEPTIDE         21..34
FT                   /note="Somatostatin-14"
FT                   /id="PRO_0000033138"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        23..34
FT   NON_TER         1
SQ   SEQUENCE   34 AA;  3963 MW;  54FF213AAF424C75 CRC64;
     AVERPRQDGQ VHEPPGRERK AGCKNFFWKT FTSC