ID   SMS_PETMA               Reviewed;          37 AA.
AC   P21779;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Somatostatin-37;
DE   Contains:
DE     RecName: Full=Somatostatin-34;
DE   Contains:
DE     RecName: Full=Somatostatin-14;
DE   Flags: Precursor;
GN   Name=sst;
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=2902094; DOI=10.1016/s0021-9258(19)37660-4;
RA   Andrews P.C., Pollock H.G., Elliott W.M., Youson J.H., Plisetskaya E.M.;
RT   "Isolation and characterization of a variant somatostatin-14 and two
RT   related somatostatins of 34 and 37 residues from lamprey (Petromyzon
RT   marinus).";
RL   J. Biol. Chem. 263:15809-15814(1988).
CC   -!- FUNCTION: Somatostatin inhibits the release of somatotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   PIR; A32000; A32000.
DR   AlphaFoldDB; P21779; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   Pfam; PF03002; Somatostatin; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Reference proteome; Secreted.
FT   PROPEP          1..2
FT                   /id="PRO_0000045872"
FT   PEPTIDE         4..37
FT                   /note="Somatostatin-34"
FT                   /id="PRO_0000033144"
FT   PEPTIDE         24..37
FT                   /note="Somatostatin-14"
FT                   /id="PRO_0000033145"
FT   DISULFID        26..37
SQ   SEQUENCE   37 AA;  4039 MW;  5918153B2775AC4D CRC64;
     ALRAAAVAGS PQQLLPLGQR ERKAGCKNFF WKTFSSC