ID   SMTL2_BOVIN             Reviewed;         458 AA.
AC   Q2KI85;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Smoothelin-like protein 2;
GN   Name=SMTNL2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the smoothelin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC112730; AAI12731.1; -; mRNA.
DR   RefSeq; NP_001039785.1; NM_001046320.1.
DR   AlphaFoldDB; Q2KI85; -.
DR   SMR; Q2KI85; -.
DR   STRING; 9913.ENSBTAP00000027457; -.
DR   PaxDb; Q2KI85; -.
DR   GeneID; 532143; -.
DR   KEGG; bta:532143; -.
DR   CTD; 342527; -.
DR   eggNOG; KOG4678; Eukaryota.
DR   HOGENOM; CLU_040651_5_0_1; -.
DR   InParanoid; Q2KI85; -.
DR   OrthoDB; 168604at2759; -.
DR   TreeFam; TF316716; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0031941; C:filamentous actin; IBA:GO_Central.
DR   GO; GO:0031674; C:I band; IBA:GO_Central.
DR   GO; GO:0031430; C:M band; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR   GO; GO:0005523; F:tropomyosin binding; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR   CDD; cd00014; CH; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   Pfam; PF00307; CH; 1.
DR   SMART; SM00033; CH; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   PROSITE; PS50021; CH; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..458
FT                   /note="Smoothelin-like protein 2"
FT                   /id="PRO_0000317277"
FT   DOMAIN          348..455
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   REGION          87..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          24..88
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        93..107
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..185
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..269
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..285
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         96
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI12"
FT   MOD_RES         98
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI12"
FT   MOD_RES         126
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI12"
FT   MOD_RES         131
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI12"
FT   MOD_RES         252
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI12"
FT   MOD_RES         254
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI12"
FT   MOD_RES         267
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI12"
FT   MOD_RES         272
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI12"
FT   MOD_RES         276
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI12"
FT   MOD_RES         341
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI12"
SQ   SEQUENCE   458 AA;  49814 MW;  C7CF1A1B0ABE37AD CRC64;
     MESAPDAEEA RTVREALGRY EAALEGAVRA LHEDMQGLQR GVEQRVAEAL RLAGPLARTV
     AELQRDNQRL QTQLERLTRQ VESLGLTTGL APAPGTPSPP PAPGVPNRAP RLGTARFASH
     ATFSLSGRSQ SLDHHDEASE LEMRRTSNSC IIENGHQPGA DPGDGPPEAT QTIPAPEPPK
     PRPVSLSLRL PHQPVTAVTR VSERFSGETS ATALSPTSAA ILGGLSSSPS EATTPWTPSP
     SEKNSSLPRS LSSSGFGAMT ASRNNNSPPL VTPPQSPPSP QPPATTQAHR PGERRRELVR
     SQTLPRTSGA QARKALFEKW EQDTAGKGKG ETRAKLKRSQ SFGVASASSI KQILLEWCRS
     KTLGYQHVDL QNFSSSWSDG MAFCALVHSF FPDAFDYNAL SPTQRRQNFE LAFTMAENLA
     NCERLIEVED MMVMGRKPDP MCVFTYVQSL YNHLRRFE