ID   SMU1_DICDI              Reviewed;         530 AA.
AC   Q54Y96;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=WD40 repeat-containing protein smu1;
GN   Name=smu1; ORFNames=DDB_G0278353;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing as a component of the
CC       spliceosome. {ECO:0000250|UniProtKB:Q2TAY7}.
CC   -!- SUBUNIT: Component of the spliceosome B complex.
CC       {ECO:0000250|UniProtKB:Q2TAY7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99M63}. Nucleus
CC       {ECO:0000250|UniProtKB:Q76B40}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q76B40}.
CC   -!- SIMILARITY: Belongs to the WD repeat SMU1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000023; EAL68349.2; -; Genomic_DNA.
DR   RefSeq; XP_642306.2; XM_637214.2.
DR   AlphaFoldDB; Q54Y96; -.
DR   SMR; Q54Y96; -.
DR   STRING; 44689.DDB0233537; -.
DR   PaxDb; Q54Y96; -.
DR   EnsemblProtists; EAL68349; EAL68349; DDB_G0278353.
DR   GeneID; 8621512; -.
DR   KEGG; ddi:DDB_G0278353; -.
DR   dictyBase; DDB_G0278353; smu1.
DR   eggNOG; KOG0275; Eukaryota.
DR   HOGENOM; CLU_000288_57_38_1; -.
DR   InParanoid; Q54Y96; -.
DR   OMA; FIEVWNY; -.
DR   PhylomeDB; Q54Y96; -.
DR   PRO; PR:Q54Y96; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR045184; SMU1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22848; PTHR22848; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00667; LisH; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50896; LISH; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Repeat; Spliceosome; WD repeat.
FT   CHAIN           1..530
FT                   /note="WD40 repeat-containing protein smu1"
FT                   /id="PRO_0000328157"
FT   DOMAIN          15..47
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   DOMAIN          49..100
FT                   /note="CTLH"
FT   REPEAT          223..262
FT                   /note="WD 1"
FT   REPEAT          273..314
FT                   /note="WD 2"
FT   REPEAT          316..357
FT                   /note="WD 3"
FT   REPEAT          358..397
FT                   /note="WD 4"
FT   REPEAT          449..490
FT                   /note="WD 5"
FT   REPEAT          491..530
FT                   /note="WD 6"
SQ   SEQUENCE   530 AA;  60437 MW;  CEE0245762D0FCB1 CRC64;
     MSNPTSTTHH NIEIQSQDVI KLILQFLKEN SLGNSLTALQ EETGINLNAV DSKETFLNDV
     KNGNWDSVLT VVSTLRLSTT LLMDLYEQIV ELLHLKEYEL CKYLIRKTEP LNYMKLNQQE
     RYLKLENHLQ REYIDLGDFY KYGITTEKRR KQLIEQLNNE IITVPSSRLL SLLSQSLHWQ
     KHQGIIPDDC MEFDLFKGEV PFKKIESEEE QITTVLDKTI KFNNKNKPET IKFSPDSKYL
     LTGSMDGFIE VWDYNTGKLS KSLAYQSNDD FMMHDDAILC IAFSKDGEFL ATGSLDNKIK
     VWQIKSGKCL RKFEPAHTNG VTCLQFSRNS TQILSGSFDS SLKIHGLKSG KALKIFRGHQ
     SFVNDCCFNH DEDRVISCSS DGKIKIWDAK SSDCLQTITP TSVVTVRDIS IRSITILLKN
     PEFLLVCNSS QISIVSMKSQ TISKTFTSEN SKTFLVCTLS PLQNYLYAVD EDNILYTFDF
     NSGSLLNKFK IHDQEVISIS HHPTKNLLAT TGSDCLLKIW KSNSNDNINN