ID   SMVA_SALT1              Reviewed;         495 AA.
AC   D0ZXQ3;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Methyl viologen resistance protein SmvA;
GN   Name=smvA; OrderedLocusNames=STM14_1900;
OS   Salmonella typhimurium (strain 14028s / SGSC 2262).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=588858;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=14028s / SGSC 2262;
RX   PubMed=19897643; DOI=10.1128/jb.01233-09;
RA   Jarvik T., Smillie C., Groisman E.A., Ochman H.;
RT   "Short-term signatures of evolutionary change in the Salmonella enterica
RT   serovar typhimurium 14028 genome.";
RL   J. Bacteriol. 192:560-567(2010).
RN   [2]
RP   FUNCTION IN RESISTANCE TO METHYL VIOLOGEN AND ACRIFLAVINE, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=14028s / SGSC 2262;
RX   PubMed=12410826; DOI=10.1046/j.1365-2958.2002.03204.x;
RA   Santiviago C.A., Fuentes J.A., Bueno S.M., Trombert A.N., Hildago A.A.,
RA   Socias L.T., Youderian P., Mora G.C.;
RT   "The Salmonella enterica sv. Typhimurium smvA, yddG and ompD (porin) genes
RT   are required for the efficient efflux of methyl viologen.";
RL   Mol. Microbiol. 46:687-698(2002).
RN   [3]
RP   FUNCTION IN EFFLUX OF QUATERNARY AMMONIUM COMPOUNDS.
RC   STRAIN=14028s / SGSC 2262;
RX   PubMed=18819967; DOI=10.1093/jac/dkn407;
RA   Villagra N.A., Hidalgo A.A., Santiviago C.A., Saavedra C.P., Mora G.C.;
RT   "SmvA, and not AcrB, is the major efflux pump for acriflavine and related
RT   compounds in Salmonella enterica serovar Typhimurium.";
RL   J. Antimicrob. Chemother. 62:1273-1276(2008).
CC   -!- FUNCTION: Major efflux pump for acriflavine and other quaternary
CC       ammonium compounds (QACs). Also required for resistance to methyl
CC       viologen. {ECO:0000269|PubMed:12410826, ECO:0000269|PubMed:18819967}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Mutants show increased sensitivity to methyl
CC       viologen and acriflavine. {ECO:0000269|PubMed:12410826}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; CP001363; ACY88371.1; -; Genomic_DNA.
DR   RefSeq; WP_000489731.1; NZ_CP043402.1.
DR   AlphaFoldDB; D0ZXQ3; -.
DR   SMR; D0ZXQ3; -.
DR   EnsemblBacteria; ACY88371; ACY88371; STM14_1900.
DR   KEGG; seo:STM14_1900; -.
DR   PATRIC; fig|588858.6.peg.1811; -.
DR   HOGENOM; CLU_000960_28_2_6; -.
DR   OMA; NLPVMAV; -.
DR   BioCyc; SENT588858:STM14_RS08745-MON; -.
DR   Proteomes; UP000002695; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..495
FT                   /note="Methyl viologen resistance protein SmvA"
FT                   /id="PRO_0000415647"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   495 AA;  52134 MW;  961F77C748CDA164 CRC64;
     MFRQWLTLVI IVLVYIPVAI DATVLHVAAP TLSMTLGASG NELLWIIDIY SLVMAGMVLP
     MGALGDRIGF KRLLMLGGTL FGLASLAAAF SHTASWLIAT RVLLAIGAAM IVPATLAGIR
     ATFCEEKHRN MALGVWAAVG SGGAAFGPLI GGILLEHFYW GSVFLINVPI VLVVMGLTAR
     YVPRQAGRRD QPLNLGHAVM LIIAILLLVY SAKTALKGHL SLWVISFTLL TGALLLGLFI
     RTQLATSRPM IDMRLFTHRI ILSGVVMAMT AMITLVGFEL LMAQELQFVH GLSPYEAGVF
     MLPVMVASGF SGPIAGVLVS RLGLRLVATG GMALSALSFY GLAMTDFSTQ QWQAWGLMAL
     LGFSAASALL ASTSAIMAAA PAEKAAAAGA IETMAYELGA GLGIAIFGLL LSRSFSASIR
     LPAGLEAQEI ARASSSMGEA VQLANSLPPT QGQAILDAAR HAFIWSHSVA LSSAGSMLLL
     LAVGMWFSLA KAQRR