SMVA_SALTY
ID SMVA_SALTY Reviewed; 495 AA.
AC P37594;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Methyl viologen resistance protein SmvA;
GN Name=smvA; OrderedLocusNames=STM1574;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SL1303;
RX PubMed=7926834; DOI=10.1016/0378-1119(94)90255-0;
RA Hongo E., Morimyo M., Mita K., Machida I., Hama-Inaba H., Tsuji H.,
RA Ichimura S., Noda Y.;
RT "The methyl viologen-resistance-encoding gene smvA of Salmonella
RT typhimurium.";
RL Gene 148:173-174(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Major efflux pump for acriflavine and other quaternary
CC ammonium compounds (QACs). Also required for resistance to methyl
CC viologen (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000305}.
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DR EMBL; D26057; BAA05055.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20492.1; -; Genomic_DNA.
DR RefSeq; NP_460533.1; NC_003197.2.
DR RefSeq; WP_000489731.1; NC_003197.2.
DR AlphaFoldDB; P37594; -.
DR SMR; P37594; -.
DR STRING; 99287.STM1574; -.
DR TCDB; 2.A.1.3.14; the major facilitator superfamily (mfs).
DR PaxDb; P37594; -.
DR EnsemblBacteria; AAL20492; AAL20492; STM1574.
DR GeneID; 1253092; -.
DR KEGG; stm:STM1574; -.
DR PATRIC; fig|99287.12.peg.1665; -.
DR HOGENOM; CLU_000960_28_2_6; -.
DR OMA; NLPVMAV; -.
DR PhylomeDB; P37594; -.
DR BioCyc; SENT99287:STM1574-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..495
FT /note="Methyl viologen resistance protein SmvA"
FT /id="PRO_0000173381"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 144
FT /note="A -> R (in Ref. 1; BAA05055)"
FT /evidence="ECO:0000305"
FT CONFLICT 147
FT /note="G -> V (in Ref. 1; BAA05055)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="V -> D (in Ref. 1; BAA05055)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="A -> V (in Ref. 1; BAA05055)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="F -> Y (in Ref. 1; BAA05055)"
FT /evidence="ECO:0000305"
FT CONFLICT 447
FT /note="L -> Y (in Ref. 1; BAA05055)"
FT /evidence="ECO:0000305"
FT CONFLICT 454..457
FT /note="AILD -> GKYLT (in Ref. 1; BAA05055)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 495 AA; 52134 MW; 961F77C748CDA164 CRC64;
MFRQWLTLVI IVLVYIPVAI DATVLHVAAP TLSMTLGASG NELLWIIDIY SLVMAGMVLP
MGALGDRIGF KRLLMLGGTL FGLASLAAAF SHTASWLIAT RVLLAIGAAM IVPATLAGIR
ATFCEEKHRN MALGVWAAVG SGGAAFGPLI GGILLEHFYW GSVFLINVPI VLVVMGLTAR
YVPRQAGRRD QPLNLGHAVM LIIAILLLVY SAKTALKGHL SLWVISFTLL TGALLLGLFI
RTQLATSRPM IDMRLFTHRI ILSGVVMAMT AMITLVGFEL LMAQELQFVH GLSPYEAGVF
MLPVMVASGF SGPIAGVLVS RLGLRLVATG GMALSALSFY GLAMTDFSTQ QWQAWGLMAL
LGFSAASALL ASTSAIMAAA PAEKAAAAGA IETMAYELGA GLGIAIFGLL LSRSFSASIR
LPAGLEAQEI ARASSSMGEA VQLANSLPPT QGQAILDAAR HAFIWSHSVA LSSAGSMLLL
LAVGMWFSLA KAQRR
