SMXL2_ARATH
ID SMXL2_ARATH Reviewed; 924 AA.
AC Q9M0C5;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Protein SMAX1-LIKE 2 {ECO:0000303|PubMed:23893171};
DE Short=AtSMXL2 {ECO:0000303|PubMed:23893171};
GN Name=SMXL2 {ECO:0000303|PubMed:23893171};
GN OrderedLocusNames=At4g30350 {ECO:0000312|Araport:AT4G30350};
GN ORFNames=F17I23.310 {ECO:0000312|EMBL:CAB81028.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INDUCTION BY KARRIKINS AND STRIGOLACTONE, TISSUE SPECIFICITY, GENE FAMILY,
RP AND NOMENCLATURE.
RX PubMed=23893171; DOI=10.1104/pp.113.221259;
RA Stanga J.P., Smith S.M., Briggs W.R., Nelson D.C.;
RT "SUPPRESSOR OF MORE AXILLARY GROWTH2 1 controls seed germination and
RT seedling development in Arabidopsis.";
RL Plant Physiol. 163:318-330(2013).
RN [4]
RP REVIEW.
RX PubMed=25179782; DOI=10.1016/j.pbi.2014.08.001;
RA Bennett T., Leyser O.;
RT "Strigolactone signalling: standing on the shoulders of DWARFs.";
RL Curr. Opin. Plant Biol. 22:7-13(2014).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=26754282; DOI=10.1007/s00425-015-2458-2;
RA Stanga J.P., Morffy N., Nelson D.C.;
RT "Functional redundancy in the control of seedling growth by the karrikin
RT signaling pathway.";
RL Planta 243:1397-1406(2016).
CC -!- FUNCTION: Probable component of a transcriptional corepressor complex
CC that acts specifically in the karrikin pathway (PubMed:26754282).
CC Controls seedling growth redundantly with SMAX1, but is not involved in
CC leaf morphology, shoot branching or germination control
CC (PubMed:26754282). {ECO:0000269|PubMed:26754282}.
CC -!- SUBUNIT: Interacts probably with TPL/TPR in an EAR-motif dependent
CC manner. {ECO:0000250|UniProtKB:Q9FHH2}.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings and leaves. Detected in
CC roots and axillary branches. {ECO:0000269|PubMed:23893171}.
CC -!- INDUCTION: Up-regulated by karrikins and strigolactone treatments.
CC {ECO:0000269|PubMed:23893171}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under continuous red light
CC (PubMed:26754282). Smax1 and smxl2 double mutants have substential
CC reduction in hypocotyl elongation (PubMed:26754282).
CC {ECO:0000269|PubMed:26754282}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL161576; CAB81028.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85755.1; -; Genomic_DNA.
DR PIR; H85354; H85354.
DR RefSeq; NP_194764.1; NM_119181.3.
DR AlphaFoldDB; Q9M0C5; -.
DR STRING; 3702.AT4G30350.1; -.
DR PaxDb; Q9M0C5; -.
DR PRIDE; Q9M0C5; -.
DR ProteomicsDB; 234474; -.
DR EnsemblPlants; AT4G30350.1; AT4G30350.1; AT4G30350.
DR GeneID; 829158; -.
DR Gramene; AT4G30350.1; AT4G30350.1; AT4G30350.
DR KEGG; ath:AT4G30350; -.
DR Araport; AT4G30350; -.
DR TAIR; locus:2118806; AT4G30350.
DR eggNOG; KOG1051; Eukaryota.
DR HOGENOM; CLU_006575_0_2_1; -.
DR InParanoid; Q9M0C5; -.
DR OMA; SKMSCCS; -.
DR OrthoDB; 173851at2759; -.
DR PhylomeDB; Q9M0C5; -.
DR PRO; PR:Q9M0C5; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9M0C5; baseline and differential.
DR GO; GO:0007623; P:circadian rhythm; IEP:TAIR.
DR GO; GO:1902347; P:response to strigolactone; IMP:TAIR.
DR Gene3D; 1.10.1780.10; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF81923; SSF81923; 1.
DR PROSITE; PS51903; CLP_R; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..924
FT /note="Protein SMAX1-LIKE 2"
FT /id="PRO_0000435711"
FT DOMAIN 8..181
FT /note="Clp R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT REGION 12..83
FT /note="Repeat 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT REGION 86..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..181
FT /note="Repeat 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT REGION 522..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 780..784
FT /note="EAR"
FT /evidence="ECO:0000305"
SQ SEQUENCE 924 AA; 101395 MW; E5C67020FD9031E2 CRC64;
MRADLITIQQ TLTPEAATVL NQSIAEATRR NHGHTTPLHV AATLLSSSSG YLRQACIKSH
PNSSHPLQCR ALELCFSVAL ERLPTTSTTT TTTSSSSSSS PSQTQEPLLS NALTAALKRA
QAHQRRGCPE QQQQPLLAVK VELEQLIISI LDDPSVSRVM REASFSSPAV KSAIEQSLIG
NSVSNSRQTG SPGIINPSAI GFGYRSVPAP VNRNLYLNPR LQQPGVGMQS GMMIQRTDEA
KRVIEIMIRT RKRNPVLVGD SEPHILVKEI LEKIENGEFS DGALRNFQVI RLEKELVSQL
ATRLGEISGL VETRIGGGGV VLDLGDLKWL VEHPAANGGA VVEMRKLLER YKGRLCFIGT
ATCETYLRCQ VYYPSMENDW DLQAIPIAAK SSLPAIFPRL GSNNNNNAML LSNNIISIES
ISPTRSFQIP MSKMSCCSRC LQSYENDVAK VEKDLTGDNR SVLPQWLQNA KANDDGDKKL
TKDQQIVELQ KKWNDLCLRL HPNQSVSERI APSTLSMMKI NTRSDITPPG SPVGTDLVLG
RPNRGLSSPE KKTREARFGK LGDSFDIDLF KKLLKGLAKS VWWQHDAASS VAAAITECKH
GNGKSKGDIW LMFTGPDRAG KSKMASALSD LVSGSQPITI SLGSSSRMDD GLNIRGKTAL
DRFAEAVRRN PFAVIVLEDI DEADILLRNN VKIAIERGRI CDSYGREVSL GNVIIILTAN
SSLGSAKNVA SIDETRLESL VNKGWELRLS VCNSSKTRKR KPNWLYSDND QTKQRKEICF
DLNEAAEFDS SSDVTVEHDQ EDNGNLVHKL VGLVDDAILF RPVDFDSIKS KTAESLKKRF
SNGLADGLTV EIEDDALERI AGAIWLSKIS LEEWLEEAMG SSLNSVKSRV SSSEDSVIRI
ELEDDLNDRI SGGYLPSSIR TVVV