ID   SN25B_CARAU             Reviewed;         203 AA.
AC   P36978; Q4VS09;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Synaptosomal-associated protein 25-B;
DE            Short=SNAP-25B;
DE   AltName: Full=Synaptosome-associated protein 25.2;
DE            Short=SNAP-25.2;
GN   Name=snap25b; Synonyms=snap25.2;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=8248151; DOI=10.1073/pnas.90.22.10598;
RA   Risinger C., Larhammar D.;
RT   "Multiple loci for synapse protein SNAP-25 in the tetraploid goldfish.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:10598-10602(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 38-203.
RC   TISSUE=Brain;
RX   PubMed=15869561; DOI=10.1111/j.1365-2826.2005.01311.x;
RA   Martyniuk C.J., Crawford A.B., Hogan N.S., Trudeau V.L.;
RT   "GABAergic modulation of the expression of genes involved in GABA synaptic
RT   transmission and stress in the hypothalamus and telencephalon of the female
RT   goldfish (Carassius auratus).";
RL   J. Neuroendocrinol. 17:269-275(2005).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=9843147;
RX   DOI=10.1002/(sici)1097-4547(19981201)54:5<563::aid-jnr1>3.0.co;2-7;
RA   Risinger C., Salaneck E., Soederberg C., Gates M., Postlethwait J.H.,
RA   Larhammar D.;
RT   "Cloning of two loci for synapse protein Snap25 in zebrafish: comparison of
RT   paralogous linkage groups suggests loss of one locus in the mammalian
RT   lineage.";
RL   J. Neurosci. Res. 54:563-573(1998).
CC   -!- FUNCTION: May play an important role in the synaptic function of
CC       specific neuronal systems. Associates with proteins involved in vesicle
CC       docking and membrane fusion.
CC   -!- SUBCELLULAR LOCATION: Synapse, synaptosome {ECO:0000250}. Cell membrane
CC       {ECO:0000250|UniProtKB:P60881}. Note=Complexed with macromolecular
CC       elements of the nerve terminal.
CC   -!- SIMILARITY: Belongs to the SNAP-25 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT84082.1; Type=Miscellaneous discrepancy; Note=Contains an extended C-terminus due to missing residues in the underlying mRNA surrounding the stop codon.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L22976; AAA16538.1; -; mRNA.
DR   EMBL; AY644725; AAT84082.1; ALT_SEQ; mRNA.
DR   PIR; I50481; I50481.
DR   AlphaFoldDB; P36978; -.
DR   SMR; P36978; -.
DR   Ensembl; ENSCART00000012232; ENSCARP00000011595; ENSCARG00000005353.
DR   Ensembl; ENSCART00000016600; ENSCARP00000015713; ENSCARG00000007305.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031201; C:SNARE complex; ISS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0017075; F:syntaxin-1 binding; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR039077; SNAP-25.
DR   InterPro; IPR000928; SNAP-25_dom.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19305:SF5; PTHR19305:SF5; 1.
DR   Pfam; PF00835; SNAP-25; 1.
DR   SMART; SM00397; t_SNARE; 2.
DR   PROSITE; PS50192; T_SNARE; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Membrane; Reference proteome; Repeat; Synapse;
KW   Synaptosome.
FT   CHAIN           1..203
FT                   /note="Synaptosomal-associated protein 25-B"
FT                   /id="PRO_0000213597"
FT   DOMAIN          19..81
FT                   /note="t-SNARE coiled-coil homology 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   DOMAIN          137..199
FT                   /note="t-SNARE coiled-coil homology 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        94
FT                   /note="K -> R (in Ref. 2; AAT84082)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   203 AA;  22664 MW;  8DFBBEDBED37D6D7 CRC64;
     MADEADMRNE LTDMQARADQ LGDESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLERI
     EEGMDQINKD MKEAEKNLTD LGNLCGLCPC PCNKLKGGGQ SWGNNQDGVV SSQPARVVDE
     REQMAISGGF IRRVTNDARE NEMDENLEQV GSIIGNLRHM ALDMGNEIDT QNRQIDRIMD
     MADSNKTRID EANQRATKML GSG