SNA29_CAEEL
ID SNA29_CAEEL Reviewed; 277 AA.
AC P83351;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 06-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Soluble NSF attachment protein 29;
GN Name=snap-29 {ECO:0000312|WormBase:K02D10.5};
GN Synonyms=phi-28 {ECO:0000312|WormBase:K02D10.5};
GN ORFNames=K02D10.5 {ECO:0000312|WormBase:K02D10.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28581477; DOI=10.1038/ncb3539;
RA Sinclair J., Pinter K., Samuel T., Beardsley S., Yuan X., Zhang J.,
RA Meng K., Yun S., Krause M., Hamza I.;
RT "Inter-organ signalling by HRG-7 promotes systemic haem homeostasis.";
RL Nat. Cell Biol. 19:799-807(2017).
CC -!- FUNCTION: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment
CC protein receptors, are essential proteins for fusion of cellular
CC membranes. SNAREs localized on opposing membranes assemble to form a
CC trans-SNARE complex, an extended, parallel four alpha-helical bundle
CC that drives membrane fusion. Plays a role in the processing and
CC secretion of the aspartic protease hrg-7 from the intestine
CC (PubMed:28581477). {ECO:0000250|UniProtKB:O95721,
CC ECO:0000269|PubMed:28581477}.
CC -!- SUBCELLULAR LOCATION: Synapse, synaptosome {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in the aberrant
CC secretion and processing of the aspartic protease hrg-7 with
CC accumulation of hrg-7 in its immature uncleaved form and in the
CC intestine. {ECO:0000269|PubMed:28581477}.
CC -!- SIMILARITY: Belongs to the SNAP-25 family. {ECO:0000305}.
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DR EMBL; BX284603; CCD71830.1; -; Genomic_DNA.
DR RefSeq; NP_498940.1; NM_066539.7.
DR AlphaFoldDB; P83351; -.
DR BioGRID; 41436; 9.
DR DIP; DIP-61373N; -.
DR IntAct; P83351; 1.
DR STRING; 6239.K02D10.5; -.
DR TCDB; 1.F.1.1.3; the synaptosomal vesicle fusion pore (svf-pore) family.
DR EPD; P83351; -.
DR PaxDb; P83351; -.
DR PeptideAtlas; P83351; -.
DR EnsemblMetazoa; K02D10.5.1; K02D10.5.1; WBGene00019305.
DR GeneID; 176233; -.
DR KEGG; cel:CELE_K02D10.5; -.
DR UCSC; K02D10.5; c. elegans.
DR CTD; 176233; -.
DR WormBase; K02D10.5; CE17152; WBGene00019305; snap-29.
DR eggNOG; KOG3065; Eukaryota.
DR GeneTree; ENSGT00950000182843; -.
DR HOGENOM; CLU_069907_0_0_1; -.
DR InParanoid; P83351; -.
DR OMA; NLDEMCD; -.
DR OrthoDB; 1187770at2759; -.
DR PhylomeDB; P83351; -.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-6811438; Intra-Golgi traffic.
DR PRO; PR:P83351; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00019305; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016324; C:apical plasma membrane; IDA:WormBase.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0055037; C:recycling endosome; IDA:WormBase.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0065002; P:intracellular protein transmembrane transport; IMP:WormBase.
DR GO; GO:0030728; P:ovulation; IMP:WormBase.
DR GO; GO:0046903; P:secretion; IMP:WormBase.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0016082; P:synaptic vesicle priming; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR InterPro; IPR000727; T_SNARE_dom.
DR SMART; SM00397; t_SNARE; 2.
DR PROSITE; PS50192; T_SNARE; 2.
PE 3: Inferred from homology;
KW Coiled coil; Protein transport; Reference proteome; Repeat; Synapse;
KW Synaptosome; Transport.
FT CHAIN 1..277
FT /note="Soluble NSF attachment protein 29"
FT /id="PRO_0000213615"
FT DOMAIN 44..106
FT /note="t-SNARE coiled-coil homology 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT DOMAIN 179..241
FT /note="t-SNARE coiled-coil homology 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 277 AA; 31115 MW; EF33EBA0ED2574B5 CRC64;
MSRNPFDDDY RPSAASSTMP VKSYTTMGHY SGEDEADYYE REIEKTLQES LDSTERSRRH
LENSEKIGTS TAQQLLEQRE KLENTEKNLD EIHRTTQMTQ RNLNSLKSFF GGMFKNKFTK
KPQEPTETPT VPQSKSASRL SETATNLSSG GGSATFSGPS GQRTLTESSR SAIKGTRWEA
MDNQIDENLD MMSANLRNLQ RLGADLGKEV DSQNEMLDRI QYKAERNDGI VRDQDKQMQK
ILGTGASTSQ TTAESLTPSM DTSTKMSLMM KATSLWK
