ID   SNAB_BOVIN              Reviewed;         298 AA.
AC   P81126; Q29RR3;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Beta-soluble NSF attachment protein;
DE            Short=SNAP-beta;
DE   AltName: Full=N-ethylmaleimide-sensitive factor attachment protein beta;
GN   Name=NAPB; Synonyms=SNAPB;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=8455721; DOI=10.1038/362353a0;
RA   Whiteheart S.W., Griff I.C., Brunner M., Clary D.O., Mayer T., Buhrow S.A.,
RA   Rothman J.E.;
RT   "SNAP family of NSF attachment proteins includes a brain-specific
RT   isoform.";
RL   Nature 362:353-355(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for vesicular transport between the endoplasmic
CC       reticulum and the Golgi apparatus.
CC   -!- SUBUNIT: Interacts with PRKCABP, and disrupts the interaction between
CC       GRIA2 and PRKCABP, leading to the internalization of GRIA2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Brain.
CC   -!- SIMILARITY: Belongs to the SNAP family. {ECO:0000305}.
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DR   EMBL; BC114061; AAI14062.1; -; mRNA.
DR   PIR; S32368; S32368.
DR   RefSeq; NP_001039698.1; NM_001046233.2.
DR   AlphaFoldDB; P81126; -.
DR   SMR; P81126; -.
DR   STRING; 9913.ENSBTAP00000043745; -.
DR   PaxDb; P81126; -.
DR   PRIDE; P81126; -.
DR   Ensembl; ENSBTAT00000046446; ENSBTAP00000043745; ENSBTAG00000032704.
DR   GeneID; 517728; -.
DR   KEGG; bta:517728; -.
DR   CTD; 63908; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032704; -.
DR   VGNC; VGNC:31882; NAPB.
DR   eggNOG; KOG1586; Eukaryota.
DR   GeneTree; ENSGT00390000005826; -.
DR   HOGENOM; CLU_046329_0_1_1; -.
DR   InParanoid; P81126; -.
DR   OMA; WSVKEYL; -.
DR   OrthoDB; 1191204at2759; -.
DR   TreeFam; TF316547; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000032704; Expressed in prefrontal cortex and 101 other tissues.
DR   ExpressionAtlas; P81126; baseline and differential.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0070044; C:synaptobrevin 2-SNAP-25-syntaxin-1a complex; IBA:GO_Central.
DR   GO; GO:0005483; F:soluble NSF attachment protein activity; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0010807; P:regulation of synaptic vesicle priming; IBA:GO_Central.
DR   GO; GO:0035494; P:SNARE complex disassembly; IBA:GO_Central.
DR   GO; GO:0035249; P:synaptic transmission, glutamatergic; IBA:GO_Central.
DR   CDD; cd15832; SNAP; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR000744; NSF_attach.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13768; PTHR13768; 1.
DR   PRINTS; PR00448; NSFATTACHMNT.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; ER-Golgi transport; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..298
FT                   /note="Beta-soluble NSF attachment protein"
FT                   /id="PRO_0000219059"
SQ   SEQUENCE   298 AA;  33555 MW;  CDA8912B93A6C27E CRC64;
     MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN MFKMAKNWSA
     AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA INCLNAAIDI YTDMGRFTIA
     AKHHITIAEI YETELVDIEK AIAHYEQSAD YYKGEESNSS ANKCLLKVAA YAAQLEQYQK
     AIEIFEQIGA NTMDNPLLKY SAKDYFFKAA LCHFIVDELN AKLALEKYEE MFPAFTDSRE
     CKLLKKLLEA HEEQNSEAYT EAVKEFDSIS RLDQWLTTML LRIKKSIQGD GEGDGDLK