ID   SNAB_RAT                Reviewed;         297 AA.
AC   P85969; A6K7C6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Beta-soluble NSF attachment protein {ECO:0000250|UniProtKB:P28663};
DE            Short=SNAP-beta {ECO:0000250|UniProtKB:P28663};
DE   AltName: Full=N-ethylmaleimide-sensitive factor attachment protein beta {ECO:0000250|UniProtKB:P28663};
GN   Name=Napb {ECO:0000250|UniProtKB:P28663};
GN   Synonyms=Snapb {ECO:0000250|UniProtKB:P28663};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=19343716; DOI=10.1002/pmic.200800664;
RA   Maurya D.K., Sundaram C.S., Bhargava P.;
RT   "Proteome profile of the mature rat olfactory bulb.";
RL   Proteomics 9:2593-2599(2009).
CC   -!- FUNCTION: Required for vesicular transport between the endoplasmic
CC       reticulum and the Golgi apparatus. {ECO:0000250|UniProtKB:P28663}.
CC   -!- SUBUNIT: Interacts with PRKCABP, and disrupts the interaction between
CC       GRIA2 and PRKCABP, leading to the internalization of GRIA2.
CC       {ECO:0000250|UniProtKB:P28663}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:19343716};
CC       Peripheral membrane protein {ECO:0000269|PubMed:19343716}.
CC   -!- SIMILARITY: Belongs to the SNAP family. {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDL95093.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH474026; EDL95093.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; P85969; -.
DR   SMR; P85969; -.
DR   CORUM; P85969; -.
DR   IntAct; P85969; 2.
DR   MINT; P85969; -.
DR   STRING; 10116.ENSRNOP00000006329; -.
DR   iPTMnet; P85969; -.
DR   PhosphoSitePlus; P85969; -.
DR   World-2DPAGE; 0004:P85969; -.
DR   jPOST; P85969; -.
DR   PaxDb; P85969; -.
DR   PRIDE; P85969; -.
DR   UCSC; RGD:1589649; rat.
DR   RGD; 1589649; Napb.
DR   eggNOG; KOG1586; Eukaryota.
DR   InParanoid; P85969; -.
DR   PhylomeDB; P85969; -.
DR   Reactome; R-RNO-204005; COPII-mediated vesicle transport.
DR   Reactome; R-RNO-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-RNO-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   Reactome; R-RNO-6811438; Intra-Golgi traffic.
DR   Reactome; R-RNO-6811440; Retrograde transport at the Trans-Golgi-Network.
DR   PRO; PR:P85969; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Proteomes; UP000234681; Chromosome 3.
DR   GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR   GO; GO:0098794; C:postsynapse; IDA:SynGO.
DR   GO; GO:0098793; C:presynapse; IDA:SynGO.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0070044; C:synaptobrevin 2-SNAP-25-syntaxin-1a complex; ISO:RGD.
DR   GO; GO:0000149; F:SNARE binding; IPI:UniProtKB.
DR   GO; GO:0005483; F:soluble NSF attachment protein activity; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IDA:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0032984; P:protein-containing complex disassembly; IDA:UniProtKB.
DR   GO; GO:0043462; P:regulation of ATP-dependent activity; IDA:UniProtKB.
DR   GO; GO:0002090; P:regulation of receptor internalization; IDA:UniProtKB.
DR   GO; GO:0010807; P:regulation of synaptic vesicle priming; ISO:RGD.
DR   GO; GO:0035494; P:SNARE complex disassembly; ISO:RGD.
DR   GO; GO:0035249; P:synaptic transmission, glutamatergic; ISO:RGD.
DR   CDD; cd15832; SNAP; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR000744; NSF_attach.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13768; PTHR13768; 1.
DR   PRINTS; PR00448; NSFATTACHMNT.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   1: Evidence at protein level;
KW   ER-Golgi transport; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..297
FT                   /note="Beta-soluble NSF attachment protein"
FT                   /id="PRO_0000349116"
SQ   SEQUENCE   297 AA;  33470 MW;  F7F38BC930148315 CRC64;
     MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN MFKMAKNWSA
     AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA INCLNAAIDI YTDMGRFTIA
     AKHHITIAEI YETELVDIEK AIAHYEQSAD YYKGEESNSA NKCLLKVAAY AAQLEQYQKA
     IEIYEQVGAN TMDNPLLKYS AKDYFFKAAL CHFIVDELNA KLALEKYEEM FPAFTDSREC
     KLLKKLLEAH EEQNSEAYTE AVKEFDSISR LDQWLTTMLL RIKKSIQGDG EGDGDLK