SNAI3_HUMAN
ID SNAI3_HUMAN Reviewed; 292 AA.
AC Q3KNW1; Q86SU5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger protein SNAI3;
DE AltName: Full=Protein snail homolog 3;
DE AltName: Full=Zinc finger protein 293;
GN Name=SNAI3; Synonyms=ZNF293;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Seems to inhibit myoblast differentiation. Transcriptional
CC repressor of E-box-dependent transactivation of downstream myogenic
CC bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-
CC CAGGTG-3' and 5'-CACCTG-3' (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: Binds E-box via C2H2-type zinc finger domain. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the snail C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; CH471184; EAW66765.1; -; Genomic_DNA.
DR EMBL; BC041461; AAH41461.1; -; mRNA.
DR EMBL; BC107058; AAI07059.1; -; mRNA.
DR CCDS; CCDS32505.1; -.
DR RefSeq; NP_840101.1; NM_178310.3.
DR AlphaFoldDB; Q3KNW1; -.
DR SMR; Q3KNW1; -.
DR BioGRID; 130614; 33.
DR IntAct; Q3KNW1; 5.
DR STRING; 9606.ENSP00000327968; -.
DR iPTMnet; Q3KNW1; -.
DR PhosphoSitePlus; Q3KNW1; -.
DR BioMuta; SNAI3; -.
DR DMDM; 121942538; -.
DR EPD; Q3KNW1; -.
DR MassIVE; Q3KNW1; -.
DR PaxDb; Q3KNW1; -.
DR PeptideAtlas; Q3KNW1; -.
DR PRIDE; Q3KNW1; -.
DR ProteomicsDB; 61707; -.
DR Antibodypedia; 17289; 131 antibodies from 26 providers.
DR DNASU; 333929; -.
DR Ensembl; ENST00000332281.6; ENSP00000327968.5; ENSG00000185669.6.
DR GeneID; 333929; -.
DR KEGG; hsa:333929; -.
DR MANE-Select; ENST00000332281.6; ENSP00000327968.5; NM_178310.4; NP_840101.1.
DR UCSC; uc002flj.4; human.
DR CTD; 333929; -.
DR DisGeNET; 333929; -.
DR GeneCards; SNAI3; -.
DR HGNC; HGNC:18411; SNAI3.
DR HPA; ENSG00000185669; Tissue enriched (skeletal).
DR MIM; 612741; gene.
DR neXtProt; NX_Q3KNW1; -.
DR OpenTargets; ENSG00000185669; -.
DR PharmGKB; PA134988226; -.
DR VEuPathDB; HostDB:ENSG00000185669; -.
DR eggNOG; KOG2462; Eukaryota.
DR GeneTree; ENSGT00940000154511; -.
DR HOGENOM; CLU_002678_42_3_1; -.
DR InParanoid; Q3KNW1; -.
DR OMA; PWDRSSA; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3KNW1; -.
DR TreeFam; TF315515; -.
DR PathwayCommons; Q3KNW1; -.
DR SignaLink; Q3KNW1; -.
DR SIGNOR; Q3KNW1; -.
DR BioGRID-ORCS; 333929; 9 hits in 1099 CRISPR screens.
DR GenomeRNAi; 333929; -.
DR Pharos; Q3KNW1; Tbio.
DR PRO; PR:Q3KNW1; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q3KNW1; protein.
DR Bgee; ENSG00000185669; Expressed in skeletal muscle tissue of rectus abdominis and 96 other tissues.
DR Genevisible; Q3KNW1; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR002355; Cu_oxidase_Cu_BS.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..292
FT /note="Zinc finger protein SNAI3"
FT /id="PRO_0000330037"
FT ZN_FING 152..174
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 183..205
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 209..231
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 237..259
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 265..287
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..20
FT /note="SNAG domain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 292 AA; 32474 MW; CF9853C07029621F CRC64;
MPRSFLVKTH SSHRVPNYRR LETQREINGA CSACGGLVVP LLPRDKEAPS VPGDLPQPWD
RSSAVACISL PLLPRIEEAL GASGLDALEV SEVDPRASRA AIVPLKDSLN HLNLPPLLVL
PTRWSPTLGP DRHGAPEKLL GAERMPRAPG GFECFHCHKP YHTLAGLARH RQLHCHLQVG
RVFTCKYCDK EYTSLGALKM HIRTHTLPCT CKICGKAFSR PWLLQGHVRT HTGEKPYACS
HCSRAFADRS NLRAHLQTHS DAKKYRCRRC TKTFSRMSLL ARHEESGCCP GP
