ID   SNAK2_SOLTU             Reviewed;         104 AA.
AC   Q93X17; A1YN11; Q948Z5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Snakin-2;
DE   Flags: Precursor;
GN   Name=SN2;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PROTEIN SEQUENCE OF 39-54,
RP   FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=cv. Jaerla; TISSUE=Tuber;
RX   PubMed=11891250; DOI=10.1104/pp.010685;
RA   Berrocal-Lobo M., Segura A., Moreno M., Lopez G., Garcia-Olmedo F.,
RA   Molina A.;
RT   "Snakin-2, an antimicrobial peptide from potato whose gene is locally
RT   induced by wounding and responds to pathogen infection.";
RL   Plant Physiol. 128:951-961(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44;
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-94.
RA   Krishnamurthy K., Contractor S.S., Silja P., Girigoudar S., Melgiri P.S.,
RA   Gai P.B.;
RT   "Cloning and characterization of Snakin2 gene from potato.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has an antimicrobial activity. Causes a rapid aggregation of
CC       both Gram-positive and Gram-negative bacteria, but the antimicrobial
CC       activity is not correlated with the capacity to aggregate bacteria.
CC       {ECO:0000269|PubMed:11891250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall.
CC   -!- TISSUE SPECIFICITY: Expressed in tubers, stems, flowers, shoot apex and
CC       leaves, but not in roots or stolons. {ECO:0000269|PubMed:11891250}.
CC   -!- INDUCTION: Locally up-regulated by abscisic acid, wounding and
CC       infection with compatible fungus. Down-regulated by gibberellic acid or
CC       infection with virulent bacteria. No responses to ethylene or abiotic
CC       stresses. {ECO:0000269|PubMed:11891250}.
CC   -!- PTM: Six disulfide bonds may be present.
CC   -!- SIMILARITY: Belongs to the GASA family. {ECO:0000305}.
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DR   EMBL; AJ312904; CAC44012.1; -; mRNA.
DR   EMBL; AJ312424; CAC44011.1; -; Genomic_DNA.
DR   EMBL; EF112176; ABL74292.1; -; Genomic_DNA.
DR   RefSeq; NP_001275092.1; NM_001288163.1.
DR   AlphaFoldDB; Q93X17; -.
DR   SMR; Q93X17; -.
DR   STRING; 4113.PGSC0003DMT400004046; -.
DR   EnsemblPlants; PGSC0003DMT400004046; PGSC0003DMT400004046; PGSC0003DMG400001598.
DR   EnsemblPlants; RHC01H1G4608.2.1; RHC01H1G4608.2.1; RHC01H1G4608.2.
DR   GeneID; 102582131; -.
DR   Gramene; PGSC0003DMT400004046; PGSC0003DMT400004046; PGSC0003DMG400001598.
DR   Gramene; RHC01H1G4608.2.1; RHC01H1G4608.2.1; RHC01H1G4608.2.
DR   KEGG; sot:102582131; -.
DR   eggNOG; ENOG502S3Z7; Eukaryota.
DR   HOGENOM; CLU_142643_1_1_1; -.
DR   InParanoid; Q93X17; -.
DR   OMA; NEKECPC; -.
DR   OrthoDB; 1576960at2759; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; Q93X17; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR003854; GASA.
DR   Pfam; PF02704; GASA; 1.
PE   1: Evidence at protein level;
KW   Antimicrobial; Cell wall; Direct protein sequencing; Disulfide bond;
KW   Plant defense; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..38
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000269|PubMed:11891250"
FT                   /id="PRO_0000348600"
FT   CHAIN           39..104
FT                   /note="Snakin-2"
FT                   /id="PRO_5000067536"
FT   CONFLICT        9..10
FT                   /note="AS -> DI (in Ref. 3; ABL74292)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13..16
FT                   /note="LSLL -> RSVQ (in Ref. 3; ABL74292)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        45
FT                   /note="D -> G (in Ref. 1; CAC44011)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   104 AA;  11038 MW;  DFB319DA4089BD97 CRC64;
     MAISKALFAS LLLSLLLLEQ VQSIQTDQVT SNAISEAAYS YKKIDCGGAC AARCRLSSRP
     RLCNRACGTC CARCNCVPPG TSGNTETCPC YASLTTHGNK RKCP