SNAT1_ORYSI
ID SNAT1_ORYSI Reviewed; 254 AA.
AC A2Y5T7; B8AZA9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2016, sequence version 3.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Serotonin N-acetyltransferase 1, chloroplastic {ECO:0000305};
DE Short=OsSNAT1 {ECO:0000305};
DE EC=2.3.1.87 {ECO:0000305};
DE AltName: Full=Nuclear shuttle protein-interacting protein homolog {ECO:0000305};
DE AltName: Full=Probable acetyltransferase NSI;
DE EC=2.3.1.-;
DE Flags: Precursor;
GN Name=SNAT1 {ECO:0000305}; Synonyms=NSI {ECO:0000305};
GN ORFNames=OsI_019680 {ECO:0000305}, OsI_20361 {ECO:0000312|EMBL:EEC79409.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Catalyzes the N-acetylation of serotonin into N-
CC acetylserotonin, the penultimate step in the synthesis of melatonin.
CC Catalyzes in vitro the N-acetylation of tryptamine to produce N-
CC acetyltryptamine, 5-methoxytryptamine to produce melatonin and tyramine
CC to produce N-acetyltyramine (By similarity). Acetyltransferase required
CC for geminivirus infection and systemic spread (By similarity).
CC {ECO:0000250|UniProtKB:Q5KQI6, ECO:0000250|UniProtKB:Q7X9V3}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-arylethylamine + acetyl-CoA = CoA + H(+) + N-acetyl-2-
CC arylethylamine; Xref=Rhea:RHEA:20497, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:55469, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:77827; EC=2.3.1.87;
CC Evidence={ECO:0000250|UniProtKB:Q5KQI6};
CC -!- PATHWAY: Aromatic compound metabolism; melatonin biosynthesis;
CC melatonin from serotonin: step 1/2. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000250|UniProtKB:Q5KQI6}. Nucleus {ECO:0000250|UniProtKB:Q7X9V3}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000130; EEC79409.1; -; Genomic_DNA.
DR AlphaFoldDB; A2Y5T7; -.
DR SMR; A2Y5T7; -.
DR STRING; 39946.A2Y5T7; -.
DR EnsemblPlants; BGIOSGA020059-TA; BGIOSGA020059-PA; BGIOSGA020059.
DR Gramene; BGIOSGA020059-TA; BGIOSGA020059-PA; BGIOSGA020059.
DR OMA; VPFHANY; -.
DR UniPathway; UPA00837; UER00815.
DR Proteomes; UP000007015; Chromosome 5.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004059; F:aralkylamine N-acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004468; F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; IEA:EnsemblPlants.
DR GO; GO:0030187; P:melatonin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0062055; P:photosynthetic state transition; IEA:EnsemblPlants.
DR GO; GO:0046739; P:transport of virus in multicellular host; IEA:EnsemblPlants.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR045039; NSI-like.
DR PANTHER; PTHR43626; PTHR43626; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Chloroplast; Melatonin biosynthesis; Nucleus; Plastid;
KW Reference proteome; Transferase; Transit peptide.
FT TRANSIT 1..83
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 84..254
FT /note="Serotonin N-acetyltransferase 1, chloroplastic"
FT /id="PRO_0000333287"
FT DOMAIN 119..254
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ SEQUENCE 254 AA; 27619 MW; D889AF498794E504 CRC64;
MASAASASAS AVVTPSSFRC VPTASCGLGA RGKAPAPRRL LHDHAQGKKR AAATWSLKAG
LWDSLRSGFL KSNNSTETVE PPSAPIEEEE PLPEELVLLE RTLADGSTEQ IIFSSAGDVN
VYDLQALCDK VGWPRRPLTK IAASLRNSYL VATLHSVTTP SKAEGEERKQ LIGMARATSD
HAFNATIWDV LVDPSYQGQG LGKALMEKVI RTLLQRDISN ITLFADNKVV DFYKNLGFEA
DPQGIKGMFW YPRF
