SND1_DANRE
ID SND1_DANRE Reviewed; 897 AA.
AC Q7ZT42; Q6DEI2; Q7SX79; Q7ZZS7; Q8AXL0;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Staphylococcal nuclease domain-containing protein 1;
DE AltName: Full=100 kDa coactivator;
DE AltName: Full=4SNc-Tudor domain protein;
DE AltName: Full=p100 co-activator;
GN Name=snd1; Synonyms=sn4tdr;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=12753931; DOI=10.1016/s0014-5793(03)00445-9;
RA Zhao C.T., Shi K.H., Su Y., Liang L.Y., Yan Y., Postlethwait J., Meng A.M.;
RT "Two variants of zebrafish p100 are expressed during embryogenesis and
RT regulated by Nodal signaling.";
RL FEBS Lett. 543:190-195(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Abe S., Wang P.;
RT "Danio rerio full mRNA for 4SNc-Tudor domain protein, complete cds.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12753931}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7ZT42-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7ZT42-2; Sequence=VSP_012670;
CC Name=3;
CC IsoId=Q7ZT42-3; Sequence=VSP_012671, VSP_012669;
CC -!- DEVELOPMENTAL STAGE: During the blastula period expressed in all
CC blastomeres. At the onset of gastrulation, expressed more in the
CC embryonic shield than in other regions. As embryos elongate, expression
CC in the shield migrates toward the animal pole and forms a longitudinal
CC band in the dorsal midline. At late gastrulation, expressed in the
CC dorsal midline extending from the tailbud to the animal pole.
CC Expression is under the control of Nodal signals.
CC {ECO:0000269|PubMed:12753931}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH77133.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAN76663.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAP23062.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC76713.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC76779.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY272050; AAP23062.1; ALT_INIT; mRNA.
DR EMBL; AF422806; AAN76663.2; ALT_INIT; mRNA.
DR EMBL; AB098074; BAC56985.1; -; mRNA.
DR EMBL; AB110096; BAC76712.1; -; mRNA.
DR EMBL; AB110096; BAC76713.1; ALT_INIT; mRNA.
DR EMBL; AB110445; BAC76779.1; ALT_INIT; mRNA.
DR EMBL; BC077133; AAH77133.1; ALT_INIT; mRNA.
DR RefSeq; NP_001280610.1; NM_001293681.1. [Q7ZT42-3]
DR AlphaFoldDB; Q7ZT42; -.
DR SMR; Q7ZT42; -.
DR STRING; 7955.ENSDARP00000040404; -.
DR PaxDb; Q7ZT42; -.
DR PeptideAtlas; Q7ZT42; -.
DR Ensembl; ENSDART00000100974; ENSDARP00000091746; ENSDARG00000006766. [Q7ZT42-3]
DR GeneID; 324404; -.
DR KEGG; dre:324404; -.
DR CTD; 27044; -.
DR ZFIN; ZDB-GENE-030131-3124; snd1.
DR eggNOG; KOG2039; Eukaryota.
DR GeneTree; ENSGT00510000047270; -.
DR HOGENOM; CLU_005966_2_0_1; -.
DR InParanoid; Q7ZT42; -.
DR PRO; PR:Q7ZT42; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000006766; Expressed in intestine and 30 other tissues.
DR ExpressionAtlas; Q7ZT42; baseline.
DR GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016442; C:RISC complex; IEA:InterPro.
DR GO; GO:0004518; F:nuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:InterPro.
DR GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR CDD; cd04508; TUDOR; 1.
DR Gene3D; 2.40.50.90; -; 5.
DR InterPro; IPR016685; Silence_cplx_Nase-comp_TudorSN.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR InterPro; IPR002071; Thermonucl_AS.
DR InterPro; IPR002999; Tudor.
DR Pfam; PF00565; SNase; 4.
DR Pfam; PF00567; TUDOR; 1.
DR PIRSF; PIRSF017179; RISC-Tudor-SN; 1.
DR SMART; SM00318; SNc; 4.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF50199; SSF50199; 5.
DR PROSITE; PS01284; TNASE_2; 1.
DR PROSITE; PS50830; TNASE_3; 4.
DR PROSITE; PS50304; TUDOR; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..897
FT /note="Staphylococcal nuclease domain-containing protein 1"
FT /id="PRO_0000183183"
FT DOMAIN 18..167
FT /note="TNase-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT DOMAIN 194..329
FT /note="TNase-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT DOMAIN 342..499
FT /note="TNase-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT DOMAIN 528..663
FT /note="TNase-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT DOMAIN 732..790
FT /note="Tudor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT VAR_SEQ 561..574
FT /note="IECPRGSRNMPGGM -> KCQPASACQLYHHL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12753931"
FT /id="VSP_012671"
FT VAR_SEQ 575..897
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12753931"
FT /id="VSP_012669"
FT VAR_SEQ 897
FT /note="R -> RYGDFRDDDADEFGYRR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12753931, ECO:0000303|Ref.3"
FT /id="VSP_012670"
FT CONFLICT 606
FT /note="I -> K (in Ref. 1; AAP23062 and 3; AAH77133)"
FT /evidence="ECO:0000305"
FT CONFLICT 612
FT /note="D -> G (in Ref. 1; AAP23062 and 3; AAH77133)"
FT /evidence="ECO:0000305"
FT CONFLICT 617
FT /note="D -> E (in Ref. 1; AAP23062 and 3; AAH77133)"
FT /evidence="ECO:0000305"
FT CONFLICT 643
FT /note="Y -> C (in Ref. 3; AAH77133)"
FT /evidence="ECO:0000305"
FT CONFLICT 669
FT /note="N -> K (in Ref. 1; AAP23062 and 3; AAH77133)"
FT /evidence="ECO:0000305"
FT CONFLICT 682..691
FT /note="GRNTDPSTSL -> VAKYRSVYVT (in Ref. 1; AAP23062 and
FT 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 753
FT /note="V -> F (in Ref. 1; AAP23062)"
FT /evidence="ECO:0000305"
FT CONFLICT 838
FT /note="M -> S (in Ref. 1; AAP23062 and 3; AAH77133)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 897 AA; 100535 MW; 367B9B6428C306A3 CRC64;
MASAVPAQVQ SSQASAPQLQ RGIVKMVLSG CAIIVRGQPR GGPPPERQIN LSNIRAGALA
RRAIQGQPDT KDTPDEPWAF QAREFMRKKV IGKEVCFTVE NKTPQGREYG MVYLGKDTSG
ENIAESLVAE GLAMVRREGI RGNNPEQVRL CDLEDQAKSS KKGLWSEGGG SHTIRDLKYT
IENPRNFVDS LHQKPVNAII EHVRDGCMVR ALLLPDYYLV TVMLSGIKSP TFKREADGSE
TPEPFAAEAK FFTESRLLQR DVQIILESCP NQVILGTILH PNGNITELLL KEGFARCVDW
SMAVYTQGAE KLRAAERSAK ERKVRIWKDY VAPTANLDQK DRQFVAKVMQ VVNADAIVVK
LNSGEYKTIH LSSIRPPRLE GEEKNKDKDK RFRPLYDIPY MFEAREFLRK KLIGKKVNVT
VDYIRAATNA MEMGVPAFPE RTCATVTIGG INIAEALVSK GLATVIRYRQ DDDQRSSHYD
ELLAAEARAI KNGKGLHSKK EVPIHRVADI SGETQKAKQF FPFLQRAGRS EAVVEYVFSG
SRLKLYMPKE TCLITFLLAG IECPRGSRNM PGGMQVAEPY SEEAMLFTKE LVLQREVEVE
VESMDIAGNF IDWLHIDGVN LSVALVENAL SKVHFTAERS SYYKTLVSAE ESARQRKEKL
WANYEEKPNE EVAQVTEAKE RGRNTDPSTS LEITDGLHFY AQDVETGTKL ENLMESMRGE
IAAQPPVEGS FAPRRGEFCI AKFADGEWYR ARVEKVESPA KVHVFYIDYG NREVLSSTRL
AALPPAFSTR TLPPQATEYA FAYIQVPQDE DARADAVDSV VRDIHNTQCL LNVEYSGMVC
PQVTLQFADT KEDVGLGLVK EGMVMVDIRK EKYLQKMVTE YLNAQESAKS ARLNIWR
