SND1_SCHPO
ID SND1_SCHPO Reviewed; 878 AA.
AC Q9Y7U7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Staphylococcal nuclease domain-containing protein 1;
DE AltName: Full=4SNc-Tudor domain protein;
GN Name=snd1 {ECO:0000312|EMBL:CAB39904.1};
GN Synonyms=sn4tdr {ECO:0000312|EMBL:BAC75640.1}; ORFNames=SPCC645.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:BAC75640.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ARC039 {ECO:0000312|EMBL:BAC75640.1};
RA Hagino T., Abe S.;
RT "Fission yeast cDNA for 4SNc-TUDOR domain protein.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:CAB39904.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16823372}.
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DR EMBL; AB108422; BAC75640.1; -; mRNA.
DR EMBL; CU329672; CAB39904.1; -; Genomic_DNA.
DR PIR; T41525; T41525.
DR RefSeq; NP_588117.1; NM_001023107.2.
DR AlphaFoldDB; Q9Y7U7; -.
DR SMR; Q9Y7U7; -.
DR BioGRID; 276051; 23.
DR STRING; 4896.SPCC645.08c.1; -.
DR iPTMnet; Q9Y7U7; -.
DR MaxQB; Q9Y7U7; -.
DR PaxDb; Q9Y7U7; -.
DR PRIDE; Q9Y7U7; -.
DR EnsemblFungi; SPCC645.08c.1; SPCC645.08c.1:pep; SPCC645.08c.
DR GeneID; 2539488; -.
DR KEGG; spo:SPCC645.08c; -.
DR PomBase; SPCC645.08c; snd1.
DR VEuPathDB; FungiDB:SPCC645.08c; -.
DR eggNOG; KOG2039; Eukaryota.
DR HOGENOM; CLU_005966_1_0_1; -.
DR InParanoid; Q9Y7U7; -.
DR OMA; FGQEAHD; -.
DR PhylomeDB; Q9Y7U7; -.
DR PRO; PR:Q9Y7U7; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016442; C:RISC complex; ISO:PomBase.
DR GO; GO:0004518; F:nuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:InterPro.
DR GO; GO:0031048; P:heterochromatin assembly by small RNA; NAS:PomBase.
DR GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR CDD; cd04508; TUDOR; 1.
DR Gene3D; 2.40.50.90; -; 5.
DR InterPro; IPR016685; Silence_cplx_Nase-comp_TudorSN.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR InterPro; IPR002999; Tudor.
DR Pfam; PF00565; SNase; 4.
DR Pfam; PF00567; TUDOR; 1.
DR PIRSF; PIRSF017179; RISC-Tudor-SN; 1.
DR SMART; SM00318; SNc; 4.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF50199; SSF50199; 5.
DR PROSITE; PS50830; TNASE_3; 4.
DR PROSITE; PS50304; TUDOR; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..878
FT /note="Staphylococcal nuclease domain-containing protein 1"
FT /id="PRO_0000315882"
FT DOMAIN 3..142
FT /note="TNase-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT DOMAIN 167..312
FT /note="TNase-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT DOMAIN 326..464
FT /note="TNase-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT DOMAIN 493..626
FT /note="TNase-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT DOMAIN 695..755
FT /note="Tudor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT MOD_RES 316
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 878 AA; 98161 MW; E437838189B5CD4C CRC64;
MSQYVSSMIK YAQSGDSFNI LIKDNAKKIT EKQFSLAYVE CPRFRREGDE PFAFEAQEFS
RRLVVGRPAS VSTLYVIPTS KREYGRIRTS EFDLAESLLR EGLAKLRPEA TRNEGTSENS
YFVSLEEAQD HAQQYKLGIW GPSDDVVVTE KANPANPAKF LKAHKGKKLN GIVETIRNGD
QVRVRLFLSP KQHQLVTISL AGVRCPRSTF TATSPEQTSS EQEPCGDEAK QFVVTRLLQR
NVVIELLDLA PNGVSFLGNV LHPAGNIATF LLSSGLGRVA DNHISALGPE TMQSLRTIER
KAKISRLGIW KNISVSIPDI NSLSLKDYSA VVSRVISTDT LEVRKDNGVE CRIQLSSIRH
PRPSNEKEAP YQLEAREFLR KKIIGKRVQV SLDFIRPGQN DLPAINNCTV KLSDGTNVAL
MVVKSGYATV IRYRMDSVDR SPIYDFLIEA EKAAQEGRKG MWSGKKPAYE NIVNASESSL
RSRQYLSSLQ RTRKLSVIIE NVISGSRFRC FCPKENCYFM FACAGIRTPR TARNDQEKGE
PFAEESLSLA KSLLQHDAQV EILSVDNNGC FLGDIYVNHD TNFALKLLSQ GLAWCQGYAS
QSNVQYSQYH DTEAAAKEQK VGMWHDYVPP EKKAASTEKE SENTVKEPIY LDIVLSDIAE
DGKFSFQIIG TGIQQLETLM SDLGSLKKSF KPSEKINVGM NVAAISALDN AMYRGRVLRC
DRENQAADVL LYDYGSVEQI PFKNISSLPD TYTKLKPQAQ LARLSYVQLP PPSSDYYEDA
RLVFRELAMN KGLVAKVDGH EGNVYSVTLY NPSDGSDFSD CINAQLVALG MASVIPKKKT
SHFEKDTASL NILEEHQQEA RLNHIGFWVY GDPLEYED
