ID   SNE_ARATH               Reviewed;         157 AA.
AC   Q9LUB6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=F-box protein SNE;
DE   AltName: Full=Protein SNEEZY;
DE   AltName: Full=Sleepy protein 2;
GN   Name=SNE; Synonyms=SLY2; OrderedLocusNames=At5g48170; ORFNames=MIF21.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT   "Arabidopsis cDNA clones.";
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, AND INTERACTION WITH SKP1A AND SKP1B.
RX   PubMed=15161962; DOI=10.1105/tpc.021386;
RA   Fu X., Richards D.E., Fleck B., Xie D., Burton N., Harberd N.P.;
RT   "The Arabidopsis mutant sleepy1gar2-1 protein promotes plant growth by
RT   increasing the affinity of the SCFSLY1 E3 ubiquitin ligase for DELLA
RT   protein substrates.";
RL   Plant Cell 16:1406-1418(2004).
RN   [5]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=15308775; DOI=10.1073/pnas.0404287101;
RA   Strader L.C., Ritchie S., Soule J.D., McGinnis K.M., Steber C.M.;
RT   "Recessive-interfering mutations in the gibberellin signaling gene SLEEPY1
RT   are rescued by overexpression of its homologue, SNEEZY.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12771-12776(2004).
CC   -!- FUNCTION: Essential component of a SCF-type E3 ligase complex that
CC       positively regulates the gibberellin signaling pathway. Upon
CC       gibberellin treatment, such complex probably mediates the
CC       ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA
CC       and RGL2), some repressors of the gibberellin pathway, leading to
CC       activate the pathway. Can partially complement the absence of
CC       GID2/SLY1. {ECO:0000269|PubMed:15161962, ECO:0000269|PubMed:15308775}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex.
CC       Interacts directly with SKP1A and SKP1B. {ECO:0000269|PubMed:15161962}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in flowers and at much lower level
CC       in seedlings, rosette leaves and green siliques.
CC       {ECO:0000269|PubMed:15308775}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB023039; BAA96997.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED95628.1; -; Genomic_DNA.
DR   EMBL; BT011771; AAS65942.1; -; mRNA.
DR   EMBL; BT012391; AAS88781.1; -; mRNA.
DR   RefSeq; NP_199628.1; NM_124191.4.
DR   AlphaFoldDB; Q9LUB6; -.
DR   BioGRID; 20116; 5.
DR   IntAct; Q9LUB6; 6.
DR   STRING; 3702.AT5G48170.1; -.
DR   PaxDb; Q9LUB6; -.
DR   PRIDE; Q9LUB6; -.
DR   DNASU; 834869; -.
DR   EnsemblPlants; AT5G48170.1; AT5G48170.1; AT5G48170.
DR   GeneID; 834869; -.
DR   Gramene; AT5G48170.1; AT5G48170.1; AT5G48170.
DR   KEGG; ath:AT5G48170; -.
DR   Araport; AT5G48170; -.
DR   TAIR; locus:2164723; AT5G48170.
DR   eggNOG; ENOG502S07N; Eukaryota.
DR   HOGENOM; CLU_111348_1_0_1; -.
DR   InParanoid; Q9LUB6; -.
DR   OMA; LMFLCKA; -.
DR   OrthoDB; 1406384at2759; -.
DR   PhylomeDB; Q9LUB6; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9LUB6; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LUB6; baseline and differential.
DR   Genevisible; Q9LUB6; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IPI:TAIR.
DR   GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IMP:TAIR.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009937; P:regulation of gibberellic acid mediated signaling pathway; IMP:TAIR.
DR   GO; GO:0048831; P:regulation of shoot system development; IGI:TAIR.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR044184; SNE.
DR   PANTHER; PTHR47750; PTHR47750; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   1: Evidence at protein level;
KW   Gibberellin signaling pathway; Nucleus; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..157
FT                   /note="F-box protein SNE"
FT                   /id="PRO_0000119964"
FT   DOMAIN          24..70
FT                   /note="F-box"
SQ   SEQUENCE   157 AA;  17966 MW;  4339CB4E8661E070 CRC64;
     MSSEKRVGMV EKSNNKRQRV NQVPVFSIND HHDVLVEILR RLDGSSLCSA ACVCRLWSAV
     ARNDSIWEEL CFRQVSPRPS LSLRSVVSAL GGYRCLYFLC IRPVLARLPK LLWTRDQLQL
     SLSLYCVHYY ERLYVGAWLG DAPPSSLIFL RKPVNVV