SNF12_ARATH
ID SNF12_ARATH Reviewed; 534 AA.
AC Q9FMT4;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=SWI/SNF complex component SNF12 homolog;
GN OrderedLocusNames=At5g14170; ORFNames=MUA22.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP STRUCTURE BY NMR OF 315-394.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the SWIB/MDM2 domain of the hypothetical protein
RT At5g14170 from Arabidopsis thaliana.";
RL Submitted (APR-2004) to the PDB data bank.
CC -!- FUNCTION: Involved in transcriptional activation and repression of
CC select genes by chromatin remodeling (alteration of DNA-nucleosome
CC topology). {ECO:0000250}.
CC -!- SUBUNIT: Part of a SWI-SNF complex. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9FMT4; Q9LQT8: GAI; NbExp=3; IntAct=EBI-3387100, EBI-963606;
CC Q9FMT4; Q9LYC1: GID1B; NbExp=3; IntAct=EBI-3387100, EBI-963686;
CC Q9FMT4; O23160: MYB73; NbExp=3; IntAct=EBI-3387100, EBI-25506855;
CC Q9FMT4; Q9SLH3: RGA; NbExp=3; IntAct=EBI-3387100, EBI-963624;
CC Q9FMT4; Q8GXW1: RGL2; NbExp=3; IntAct=EBI-3387100, EBI-963665;
CC Q9FMT4; Q9LF53: RGL3; NbExp=3; IntAct=EBI-3387100, EBI-15681313;
CC Q9FMT4; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-3387100, EBI-15192325;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMARCD family. {ECO:0000305}.
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DR EMBL; AB007650; BAB08296.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91995.1; -; Genomic_DNA.
DR EMBL; BT008892; AAP68331.1; -; mRNA.
DR EMBL; AY065106; AAL38282.1; -; mRNA.
DR RefSeq; NP_196921.1; NM_121421.4.
DR PDB; 1V31; NMR; -; A=315-394.
DR PDBsum; 1V31; -.
DR AlphaFoldDB; Q9FMT4; -.
DR BMRB; Q9FMT4; -.
DR SMR; Q9FMT4; -.
DR BioGRID; 16545; 116.
DR IntAct; Q9FMT4; 23.
DR STRING; 3702.AT5G14170.1; -.
DR iPTMnet; Q9FMT4; -.
DR PaxDb; Q9FMT4; -.
DR PRIDE; Q9FMT4; -.
DR ProteomicsDB; 232641; -.
DR EnsemblPlants; AT5G14170.1; AT5G14170.1; AT5G14170.
DR GeneID; 831267; -.
DR Gramene; AT5G14170.1; AT5G14170.1; AT5G14170.
DR KEGG; ath:AT5G14170; -.
DR Araport; AT5G14170; -.
DR TAIR; locus:2174638; AT5G14170.
DR eggNOG; KOG2570; Eukaryota.
DR HOGENOM; CLU_023529_1_0_1; -.
DR InParanoid; Q9FMT4; -.
DR OMA; PYFWNSD; -.
DR OrthoDB; 1027566at2759; -.
DR PhylomeDB; Q9FMT4; -.
DR EvolutionaryTrace; Q9FMT4; -.
DR PRO; PR:Q9FMT4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FMT4; baseline and differential.
DR Genevisible; Q9FMT4; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IMP:TAIR.
DR GO; GO:0009909; P:regulation of flower development; IMP:TAIR.
DR GO; GO:0010468; P:regulation of gene expression; IDA:TAIR.
DR GO; GO:2000024; P:regulation of leaf development; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010224; P:response to UV-B; IEP:TAIR.
DR GO; GO:0048364; P:root development; IMP:TAIR.
DR Gene3D; 1.10.245.10; -; 1.
DR InterPro; IPR019835; SWIB_domain.
DR InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR InterPro; IPR003121; SWIB_MDM2_domain.
DR Pfam; PF02201; SWIB; 1.
DR SMART; SM00151; SWIB; 1.
DR SUPFAM; SSF47592; SSF47592; 1.
DR PROSITE; PS51925; SWIB_MDM2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromatin regulator; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..534
FT /note="SWI/SNF complex component SNF12 homolog"
FT /id="PRO_0000220617"
FT DOMAIN 314..391
FT /note="SWIB/MDM2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01273"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 323..328
FT /evidence="ECO:0007829|PDB:1V31"
FT STRAND 332..334
FT /evidence="ECO:0007829|PDB:1V31"
FT HELIX 337..349
FT /evidence="ECO:0007829|PDB:1V31"
FT STRAND 358..362
FT /evidence="ECO:0007829|PDB:1V31"
FT HELIX 366..370
FT /evidence="ECO:0007829|PDB:1V31"
FT STRAND 373..377
FT /evidence="ECO:0007829|PDB:1V31"
FT TURN 378..381
FT /evidence="ECO:0007829|PDB:1V31"
FT HELIX 382..388
FT /evidence="ECO:0007829|PDB:1V31"
SQ SEQUENCE 534 AA; 59271 MW; 4231FF2324C18D9D CRC64;
MSGNNNNPQK PQGSAPLPFG NPGMASASVP GNQGFAQSHM AANFQAQFQF SQAQALAHAQ
AQSKVQAQLQ AQLQAQGMTM NQAQGSPGIG GLGPSSPSLT TPGSLNMKRF QQKPPMRPPG
APASNNTISP MRTMELTPAA RKKKQKLPEK SLQERVAAIL PESALYTQLL EFESRVDAAL
TRKKVDIQEA LKNPPCIQKT LRIYVFNSFA NQNNTIPGNP NADPPTWTLK IIGRILEDGV
DPDQPGFVQK ANPLHPKFSS FFKRVTVSLD QRLYPENPLI IWENARSPAP QEGFEIKRKG
NQEFAASIRL EMNYVPEKFK LSTALMDVLG IEVETRPRII AAIWHYVKAR KLQNPNDPSF
FNCDAALQKV FGEEKLKFTM VSQKISHHLS PPPPIHLEHK IKLSGNNPAV SACYDVLVDV
PFPIQRDLNN LLANAEKNKE IEACDEAICA AIRKIHEHRR RRAFFLGFSQ SPVEFINALI
ESQSKDLKVV AGEASRNAER ERRSDFFNQP WVEDAVIRYL NRRPAAGNDG PGSW
