ID   SNF12_DICDI             Reviewed;         456 AA.
AC   Q556Z0; Q86JT1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=SWI/SNF complex component SNF12 homolog;
GN   Name=snf12-1; ORFNames=DDB_G0273203;
GN   and
GN   Name=snf12-2; ORFNames=DDB_G0273725;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in transcriptional activation and repression of
CC       select genes by chromatin remodeling (alteration of DNA-nucleosome
CC       topology). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a SWI-SNF complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SMARCD family. {ECO:0000305}.
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC       AX4. These strains contain a duplication of a segment of 750 kb of
CC       chromosome 2 compared to the corresponding sequence in strain AX2.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000011; EAL70553.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70819.1; -; Genomic_DNA.
DR   RefSeq; XP_644479.1; XM_639387.1.
DR   RefSeq; XP_644771.1; XM_639679.1.
DR   AlphaFoldDB; Q556Z0; -.
DR   SMR; Q556Z0; -.
DR   STRING; 44689.DDB0233489; -.
DR   PaxDb; Q556Z0; -.
DR   EnsemblProtists; EAL70553; EAL70553; DDB_G0273725.
DR   EnsemblProtists; EAL70819; EAL70819; DDB_G0273203.
DR   GeneID; 8618873; -.
DR   GeneID; 8619103; -.
DR   KEGG; ddi:DDB_G0273203; -.
DR   KEGG; ddi:DDB_G0273725; -.
DR   dictyBase; DDB_G0273203; snf12-1.
DR   dictyBase; DDB_G0273725; snf12-2.
DR   eggNOG; KOG2570; Eukaryota.
DR   HOGENOM; CLU_023529_2_1_1; -.
DR   InParanoid; Q556Z0; -.
DR   OMA; PYFWNSD; -.
DR   PhylomeDB; Q556Z0; -.
DR   Reactome; R-DDI-3214858; RMTs methylate histone arginines.
DR   PRO; PR:Q556Z0; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0005730; C:nucleolus; IDA:dictyBase.
DR   GO; GO:0005654; C:nucleoplasm; IDA:dictyBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.245.10; -; 1.
DR   InterPro; IPR019835; SWIB_domain.
DR   InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR   InterPro; IPR003121; SWIB_MDM2_domain.
DR   Pfam; PF02201; SWIB; 1.
DR   SMART; SM00151; SWIB; 1.
DR   SUPFAM; SSF47592; SSF47592; 1.
DR   PROSITE; PS51925; SWIB_MDM2; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..456
FT                   /note="SWI/SNF complex component SNF12 homolog"
FT                   /id="PRO_0000328578"
FT   DOMAIN          234..310
FT                   /note="SWIB/MDM2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01273"
FT   REGION          435..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   456 AA;  52001 MW;  93A7CF7088C4E8BA CRC64;
     MSKNGTTGNK KKKTKLSTAA TIAANIAKAN ATLNNNNNSN NNSNNTNIGN SINGIPSSLP
     PSVTLPVEEL ISFAPECLLF SQLLEFEEKL DASINKRLID IQEASRRNSI KNIRTLRLSI
     YNTYSNQSAY YHLDNKSLNS VQERPSWSLR VEGKLLDESQ DELVNKSIKS SSSSSSTANK
     RKFSSFFKKV FIQIGHRDTC EWDKSQTFTE TDGFEIKRNG NQEVDIKILM YLDHVPQKYK
     VLGGLSQLLN IHTDTKPRII LALWHYIKSN TLLDAETKKI TCDENLKNIF SLEELQFNQI
     PQLLREHLSP PDPLEFQYTL HLSGDAKDYE QAYDIQVEVD EPIFNPNPTM RKEISQLNDE
     INHHIQKVYQ HKRKREFMEK LSSDPLGFLN DTTANLVKDF QVSKSTTSTG FEEERHASFY
     YQPMTEELVK NYLSKQTTPN PTPQQISMAP STPQTP