SNF5_CHICK
ID SNF5_CHICK Reviewed; 386 AA.
AC Q5ZK40;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;
GN Name=SMARCB1; ORFNames=RCJMB04_13f19;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Involved in chromatin-remodeling. Core component of the BAF
CC (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex
CC plays important roles in cell proliferation and differentiation, in
CC cellular antiviral activities and inhibition of tumor formation.
CC Belongs to the neural progenitors-specific chromatin remodeling complex
CC (npBAF complex) and the neuron-specific chromatin remodeling complex
CC (nBAF complex) and may play a role in neural development (By
CC similarity). {ECO:0000250|UniProtKB:Q12824}.
CC -!- SUBUNIT: Component of the multiprotein chromatin-remodeling complexes
CC SWI/SNF. Component of neural progenitors-specific chromatin remodeling
CC complex (npBAF complex) and the neuron-specific chromatin remodeling
CC complex (nBAF complex) (By similarity). Component of the BAF (SWI/SNF)
CC chromatin remodeling complex. Component of the SWI/SNF-B (PBAF)
CC chromatin remodeling complex. Binds to double-stranded DNA.
CC {ECO:0000250|UniProtKB:Q12824, ECO:0000250|UniProtKB:Q9Z0H3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The N-terminal DNA-binding region is structurally similar to
CC winged helix domains. {ECO:0000250|UniProtKB:Q12824}.
CC -!- SIMILARITY: Belongs to the SNF5 family. {ECO:0000305}.
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DR EMBL; AJ720244; CAG31903.1; -; mRNA.
DR RefSeq; NP_001034344.1; NM_001039255.1.
DR AlphaFoldDB; Q5ZK40; -.
DR SMR; Q5ZK40; -.
DR STRING; 9031.ENSGALP00000009608; -.
DR PaxDb; Q5ZK40; -.
DR Ensembl; ENSGALT00000009622; ENSGALP00000009608; ENSGALG00000005983.
DR GeneID; 769489; -.
DR KEGG; gga:769489; -.
DR CTD; 6598; -.
DR VEuPathDB; HostDB:geneid_769489; -.
DR eggNOG; KOG1649; Eukaryota.
DR GeneTree; ENSGT00440000038585; -.
DR HOGENOM; CLU_035084_0_0_1; -.
DR InParanoid; Q5ZK40; -.
DR OMA; QLWKRMA; -.
DR OrthoDB; 790205at2759; -.
DR PhylomeDB; Q5ZK40; -.
DR TreeFam; TF105993; -.
DR Reactome; R-GGA-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR PRO; PR:Q5ZK40; -.
DR Proteomes; UP000000539; Chromosome 15.
DR Bgee; ENSGALG00000005983; Expressed in ovary and 12 other tissues.
DR GO; GO:0035060; C:brahma complex; IBA:GO_Central.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0043073; C:germ cell nucleus; IEA:Ensembl.
DR GO; GO:0071565; C:nBAF complex; IBA:GO_Central.
DR GO; GO:0071564; C:npBAF complex; IBA:GO_Central.
DR GO; GO:0000228; C:nuclear chromosome; IEA:InterPro.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR GO; GO:0001164; F:RNA polymerase I core promoter sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0030957; F:Tat protein binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0070365; P:hepatocyte differentiation; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:1900110; P:negative regulation of histone H3-K9 dimethylation; IEA:Ensembl.
DR GO; GO:1900113; P:negative regulation of histone H3-K9 trimethylation; IEA:Ensembl.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006337; P:nucleosome disassembly; IEA:Ensembl.
DR GO; GO:0043923; P:positive regulation by host of viral transcription; IEA:Ensembl.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:1902661; P:positive regulation of glucose mediated signaling pathway; IEA:Ensembl.
DR GO; GO:2000617; P:positive regulation of histone H3-K9 acetylation; IEA:Ensembl.
DR GO; GO:0090240; P:positive regulation of histone H4 acetylation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1901838; P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0039692; P:single stranded viral RNA replication via double stranded DNA intermediate; IEA:Ensembl.
DR InterPro; IPR017393; Sfh1/SNF5.
DR InterPro; IPR006939; SNF5.
DR Pfam; PF04855; SNF5; 1.
DR PIRSF; PIRSF038126; SWI_SNF; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Neurogenesis; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..386
FT /note="SWI/SNF-related matrix-associated actin-dependent
FT regulator of chromatin subfamily B member 1"
FT /id="PRO_0000205950"
FT REGION 1..114
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:Q12824"
SQ SEQUENCE 386 AA; 44496 MW; B51EA2A52E65CDF5 CRC64;
MMMMALSKTF GQKPVKFQLE EDGEFYMIGS EVGNYLRMFR GSLYKRYPSL WRRLATVEER
KKIVASSHEN QRSHSPRRYH GYTTLATSVT LLKASEVEEI LDGNDEKYKA VSISTEPPTY
LREQKAKRNN QWVPTLPNSS HHLDAVPCST TINRNRMGRD KKRTFPLCFD DHDPAVIHEN
ASQPEVLVPI RLDMEIDGQK LRDAFTWNMN EKLMTPEMFS EILCDDLDLN PLTFVPAIAS
AIRQQIESYP TDSILEDQSD QRVIIKLNIH VGNISLVDQF EWDMSEKENS PEKFALKLCS
ELGLGGEFVT TIAYSIRGQL SWHQKTYAFS ENPLPTVEIA IRNTGDADQW CPLLETLTDA
EMEKKIRDQD RNTRRMRRLA NTAPAW
