ID   SNF5_DANRE              Reviewed;         373 AA.
AC   Q5U379;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-A;
GN   Name=smarcb1a; Synonyms=smarcb1; ORFNames=zgc:92517;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in chromatin-remodeling. Core component of the BAF
CC       (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex
CC       plays important roles in cell proliferation and differentiation, in
CC       cellular antiviral activities and inhibition of tumor formation.
CC       Belongs to the neural progenitors-specific chromatin remodeling complex
CC       (npBAF complex) and the neuron-specific chromatin remodeling complex
CC       (nBAF complex) and may play a role in neural development (By
CC       similarity). {ECO:0000250|UniProtKB:Q12824}.
CC   -!- SUBUNIT: Component of the multiprotein chromatin-remodeling complexes
CC       SWI/SNF. Component of neural progenitors-specific chromatin remodeling
CC       complex (npBAF complex) and the neuron-specific chromatin remodeling
CC       complex (nBAF complex) (By similarity). Component of the BAF (SWI/SNF)
CC       chromatin remodeling complex. Component of the SWI/SNF-B (PBAF)
CC       chromatin remodeling complex. Binds to double-stranded DNA (By
CC       similarity). {ECO:0000250|UniProtKB:Q12824,
CC       ECO:0000250|UniProtKB:Q9Z0H3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal DNA-binding region is structurally similar to
CC       winged helix domains. {ECO:0000250|UniProtKB:Q12824}.
CC   -!- SIMILARITY: Belongs to the SNF5 family. {ECO:0000305}.
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DR   EMBL; BC085668; AAH85668.1; -; mRNA.
DR   RefSeq; NP_001007297.1; NM_001007296.1.
DR   AlphaFoldDB; Q5U379; -.
DR   SMR; Q5U379; -.
DR   STRING; 7955.ENSDARP00000049943; -.
DR   PaxDb; Q5U379; -.
DR   Ensembl; ENSDART00000011318; ENSDARP00000004210; ENSDARG00000111561.
DR   Ensembl; ENSDART00000049944; ENSDARP00000049943; ENSDARG00000033647.
DR   GeneID; 799716; -.
DR   KEGG; dre:799716; -.
DR   CTD; 799716; -.
DR   ZFIN; ZDB-GENE-041114-5; smarcb1a.
DR   eggNOG; KOG1649; Eukaryota.
DR   GeneTree; ENSGT00440000038585; -.
DR   HOGENOM; CLU_035084_0_0_1; -.
DR   InParanoid; Q5U379; -.
DR   OMA; QLWKRMA; -.
DR   OrthoDB; 790205at2759; -.
DR   PhylomeDB; Q5U379; -.
DR   TreeFam; TF105993; -.
DR   PRO; PR:Q5U379; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000033647; Expressed in mature ovarian follicle and 27 other tissues.
DR   ExpressionAtlas; Q5U379; baseline and differential.
DR   GO; GO:0035060; C:brahma complex; IBA:GO_Central.
DR   GO; GO:0071565; C:nBAF complex; IBA:GO_Central.
DR   GO; GO:0071564; C:npBAF complex; IBA:GO_Central.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR017393; Sfh1/SNF5.
DR   InterPro; IPR006939; SNF5.
DR   Pfam; PF04855; SNF5; 2.
DR   PIRSF; PIRSF038126; SWI_SNF; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..373
FT                   /note="SWI/SNF-related matrix-associated actin-dependent
FT                   regulator of chromatin subfamily B member 1-A"
FT                   /id="PRO_0000205953"
FT   REGION          1..101
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q12824"
SQ   SEQUENCE   373 AA;  42783 MW;  128C77BCF0150400 CRC64;
     MALSKTYGQK PIKFQLEEDG DFYMIGSEVG NYLRMFRGSL YKRYPSLSRR LATVEERKKI
     VASSHDHGYT TLATSVTLLK ASEVEEIFDG HDEKYKAVSI STEPPAYLRE QKAKRNSQWV
     PTLPNSSHHL DAVPCSTTIN RNRMGRDKKR TFPLCFDDHD PAVIHENASQ QEVLVPIRLD
     MEIDGQKLRD AFTWNMNEKL MTPEMFAEIL CDDLDLSPLT FVPAIASAIR QQIESYPTDS
     ILDEQMDQRV IIKLNIHVGN ISLVDQFEWD MSEKENSPEK FALKLCSELG LGGEFVTTIA
     YSIRGQLSWH QRTYAFSENP LPTVEIAIRN TGDADQWCPL LETLTDAEME KKIRDQDRNT
     RRMRRLANTA PAW