ID   SNF5_SCHPO              Reviewed;         632 AA.
AC   Q09699;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=SWI/SNF chromatin-remodeling complex subunit snf5;
DE   AltName: Full=SWI/SNF complex subunit snf5;
GN   Name=snf5; ORFNames=SPAC2F7.08c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   IDENTIFICATION IN THE SWI/SNF COMPLEX, FUNCTION OF THE SWI/SNF COMPLEX, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18622392; DOI=10.1038/nsmb.1452;
RA   Monahan B.J., Villen J., Marguerat S., Baehler J., Gygi S.P., Winston F.;
RT   "Fission yeast SWI/SNF and RSC complexes show compositional and functional
RT   differences from budding yeast.";
RL   Nat. Struct. Mol. Biol. 15:873-880(2008).
CC   -!- FUNCTION: Component of the SWI/SNF complex, an ATP-dependent chromatin
CC       remodeling complex, required for the positive and negative regulation
CC       of gene expression of a large number of genes. It changes chromatin
CC       structure by altering DNA-histone contacts within a nucleosome, leading
CC       eventually to a change in nucleosome position, thus facilitating or
CC       repressing binding of gene-specific transcription factors.
CC       {ECO:0000269|PubMed:18622392}.
CC   -!- SUBUNIT: Component of the SWI/SNF global transcription activator
CC       complex composed of at least arp9, arp42, snf5, snf22, snf30, sbf59,
CC       sol1, ssr1, ssr2, ssr3, ssr4 and tfg3. {ECO:0000269|PubMed:18622392}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SNF5 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA90495.1; -; Genomic_DNA.
DR   PIR; T38556; S58152.
DR   RefSeq; NP_592979.1; NM_001018379.1.
DR   AlphaFoldDB; Q09699; -.
DR   SMR; Q09699; -.
DR   BioGRID; 278292; 306.
DR   ComplexPortal; CPX-6362; SWI/SNF chromatin remodelling complex.
DR   DIP; DIP-48379N; -.
DR   IntAct; Q09699; 11.
DR   STRING; 4896.SPAC2F7.08c.1; -.
DR   iPTMnet; Q09699; -.
DR   MaxQB; Q09699; -.
DR   PaxDb; Q09699; -.
DR   PRIDE; Q09699; -.
DR   EnsemblFungi; SPAC2F7.08c.1; SPAC2F7.08c.1:pep; SPAC2F7.08c.
DR   GeneID; 2541801; -.
DR   KEGG; spo:SPAC2F7.08c; -.
DR   PomBase; SPAC2F7.08c; snf5.
DR   VEuPathDB; FungiDB:SPAC2F7.08c; -.
DR   eggNOG; KOG1649; Eukaryota.
DR   HOGENOM; CLU_018784_0_0_1; -.
DR   InParanoid; Q09699; -.
DR   OMA; IDADRYK; -.
DR   PhylomeDB; Q09699; -.
DR   PRO; PR:Q09699; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000785; C:chromatin; IC:ComplexPortal.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016514; C:SWI/SNF complex; IDA:PomBase.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IC:ComplexPortal.
DR   GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; IC:ComplexPortal.
DR   GO; GO:1900400; P:regulation of iron ion import into cell by regulation of transcription from RNA polymerase II promoter; IMP:PomBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:PomBase.
DR   InterPro; IPR006939; SNF5.
DR   Pfam; PF04855; SNF5; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..632
FT                   /note="SWI/SNF chromatin-remodeling complex subunit snf5"
FT                   /id="PRO_0000205963"
SQ   SEQUENCE   632 AA;  71915 MW;  7153CFA105690953 CRC64;
     MDKDIGSAVA ELQVCSTHYA MTIVSCGFHS PQSLMNADLQ HCLLADQNYL LNNSNKNKGS
     IIEENTRKPF QSARNLQTSL KTHPESAITR YGLGYAGFGN GWTALKPKIL FPSQKRRVKG
     RFTFPFSRRS NLAQSKLPVD LVPIRLEIDA DRYKLRDSFT WNLYDKCISL DQFAEQICID
     YDIPLHNVHI VQNISKSIQA QINDYEPRKA QSNLSFVSDV SSSTSETVYA HEPSDSLAKA
     SKQQIPTVQN DLRILIKLDI TIGRLNLIDQ FEWNLFAPES SAEEFATVMC LDLGLSGEFC
     TAVAHSIREQ CQMYIKYLSL IGYLFDGSEI EDEEVRSYIL PPLKNTLRFS DMESSSFAPM
     IYELNDAEME RQDRGYDREA RRMRRRQGRA KHGIMLPDLR DIPKIHRSLF PSSSVPSDDD
     FMHALSLSTN SDGETLNEIN TNNPEREHLI VRLKVDSQKL KIIVEQSQTL TLNNFQQRKL
     TPLPNSMSFD SLNEFESERN TPSTYGQNIS PLPQFSSPSL SSDAFLTNSN SSESALVHMQ
     KLNLPDFTPS WVKRCVIETF AKFPNDRFNV IVKPALNPAE RMTVRICCHD CINEYFTAGP
     GFTFGNFHIH LLSSSHQQKK EVRMNTVLDR NT