ID   SNF5_TETFL              Reviewed;         373 AA.
AC   O42467;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;
GN   Name=smarcb1; Synonyms=snf5;
OS   Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=47145;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Yao C.W., Leu J.H., Huang C.J.;
RT   "Genomic structure and sequence of SNF5 gene of puffer fish (Tetraodon
RT   fluviatilis).";
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in chromatin-remodeling. Core component of the BAF
CC       (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex
CC       plays important roles in cell proliferation and differentiation, in
CC       cellular antiviral activities and inhibition of tumor formation.
CC       Belongs to the neural progenitors-specific chromatin remodeling complex
CC       (npBAF complex) and the neuron-specific chromatin remodeling complex
CC       (nBAF complex) and may play a role in neural development (By
CC       similarity). {ECO:0000250|UniProtKB:Q12824}.
CC   -!- SUBUNIT: Component of the multiprotein chromatin-remodeling complexes
CC       SWI/SNF. Component of neural progenitors-specific chromatin remodeling
CC       complex (npBAF complex) and the neuron-specific chromatin remodeling
CC       complex (nBAF complex) (By similarity). Component of the BAF (SWI/SNF)
CC       chromatin remodeling complex. Component of the SWI/SNF-B (PBAF)
CC       chromatin remodeling complex. Binds to double-stranded DNA (By
CC       similarity). {ECO:0000250|UniProtKB:Q12824,
CC       ECO:0000250|UniProtKB:Q9Z0H3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal DNA-binding region is structurally similar to
CC       winged helix domains. {ECO:0000250|UniProtKB:Q12824}.
CC   -!- SIMILARITY: Belongs to the SNF5 family. {ECO:0000305}.
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DR   EMBL; AF007218; AAB62935.1; -; Genomic_DNA.
DR   AlphaFoldDB; O42467; -.
DR   SMR; O42467; -.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:InterPro.
DR   GO; GO:0070603; C:SWI/SNF superfamily-type complex; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   InterPro; IPR017393; Sfh1/SNF5.
DR   InterPro; IPR006939; SNF5.
DR   Pfam; PF04855; SNF5; 2.
DR   PIRSF; PIRSF038126; SWI_SNF; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Neurogenesis; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..373
FT                   /note="SWI/SNF-related matrix-associated actin-dependent
FT                   regulator of chromatin subfamily B member 1"
FT                   /id="PRO_0000205954"
FT   REGION          1..101
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q12824"
SQ   SEQUENCE   373 AA;  42535 MW;  09EEFF6F9F652559 CRC64;
     MALSKAFGQK PVKFQLEDGG DFYMIGSEVG NYLRMFRGSL YKRYPSLWRK LASVEERKKI
     VESSHDHGYT QLATSVTLLK ASEVEEILDG NDEKYKAVSI STEPPAYLRE QKAKRNSQWV
     PTLPNSSHHL DAVPCSTTIN RSRLGRDKKR TFPLCFDDHD PAVIHENASQ SEVLVPIRLD
     MEIEGQKLRD AFTWNMNEKL MTPEMFAEIL CDDLDLNPLA FVPAIPSAIR QQIESYPTDA
     ILEEQTDQRV IIKLNIHVGN ISLVDQFEWD MSEKENSPEK FALKLCSELG QGGEFVTTIA
     YSIRGQLSWH QKAYAFSENP LPTVEIAIRN TGAADQWCPL LETLTDAEME KKIRDQDRNT
     RRIRRLANTA PGW