SNF5_XENTR
ID SNF5_XENTR Reviewed; 378 AA.
AC Q6DFM1;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;
GN Name=smarcb1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in chromatin-remodeling. Core component of the BAF
CC (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex
CC plays important roles in cell proliferation and differentiation, in
CC cellular antiviral activities and inhibition of tumor formation.
CC Belongs to the neural progenitors-specific chromatin remodeling complex
CC (npBAF complex) and the neuron-specific chromatin remodeling complex
CC (nBAF complex) and may play a role in neural development (By
CC similarity). {ECO:0000250|UniProtKB:Q12824}.
CC -!- SUBUNIT: Component of the multiprotein chromatin-remodeling complexes
CC SWI/SNF. Component of neural progenitors-specific chromatin remodeling
CC complex (npBAF complex) and the neuron-specific chromatin remodeling
CC complex (nBAF complex) (By similarity). Component of the BAF (SWI/SNF)
CC chromatin remodeling complex. Component of the SWI/SNF-B (PBAF)
CC chromatin remodeling complex. Binds to double-stranded DNA (By
CC similarity). {ECO:0000250|UniProtKB:Q12824,
CC ECO:0000250|UniProtKB:Q9Z0H3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The N-terminal DNA-binding region is structurally similar to
CC winged helix domains. {ECO:0000250|UniProtKB:Q12824}.
CC -!- SIMILARITY: Belongs to the SNF5 family. {ECO:0000305}.
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DR EMBL; BC076714; AAH76714.1; -; mRNA.
DR RefSeq; NP_001006819.1; NM_001006818.1.
DR AlphaFoldDB; Q6DFM1; -.
DR SMR; Q6DFM1; -.
DR STRING; 8364.ENSXETP00000028640; -.
DR PaxDb; Q6DFM1; -.
DR DNASU; 448543; -.
DR Ensembl; ENSXETT00000048417; ENSXETP00000048417; ENSXETG00000022368.
DR GeneID; 448543; -.
DR KEGG; xtr:448543; -.
DR CTD; 6598; -.
DR Xenbase; XB-GENE-493598; smarcb1.
DR eggNOG; KOG1649; Eukaryota.
DR HOGENOM; CLU_035084_0_0_1; -.
DR InParanoid; Q6DFM1; -.
DR OrthoDB; 790205at2759; -.
DR PhylomeDB; Q6DFM1; -.
DR Reactome; R-XTR-3214858; RMTs methylate histone arginines.
DR Reactome; R-XTR-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000022368; Expressed in gastrula and 14 other tissues.
DR GO; GO:0035060; C:brahma complex; IBA:GO_Central.
DR GO; GO:0071565; C:nBAF complex; IBA:GO_Central.
DR GO; GO:0071564; C:npBAF complex; IBA:GO_Central.
DR GO; GO:0000228; C:nuclear chromosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR017393; Sfh1/SNF5.
DR InterPro; IPR006939; SNF5.
DR Pfam; PF04855; SNF5; 2.
DR PIRSF; PIRSF038126; SWI_SNF; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..378
FT /note="SWI/SNF-related matrix-associated actin-dependent
FT regulator of chromatin subfamily B member 1"
FT /id="PRO_0000205952"
FT REGION 1..106
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:Q12824"
SQ SEQUENCE 378 AA; 43328 MW; CEADA55C9B8B7D92 CRC64;
MIMALSKTFG QKPVKFQLEE DGEYYMIGSE VGNYLRMFRG SLYKRYPSLW RRLATVEERK
KIVASSHGKK YHGYTTLATS VTLLKASEVE EILDGNDEKY KAVSISTEPP TYLREQKAKR
NSQWVPTLPN SSHHLDAVPC STTINRNRMG RDKKRTFPLC FDDHDPAVIH ENAAQSEVLV
PIRLDMEIDG QKLRDAFTWN MNEKLMTPEM FAEILCDDLD LNPLAFVPAI ASAIRQQIES
YPTDSILEDQ SDQRVIIKLN IHVGNISLVD QFEWDMSEKE NSPEKFALKL CSELGLGGEF
VTTIAYSIRG QLSWHQKTYA FSENPLPTVE IAIRNTGDAD QWCPLLETLT DAEMEKKIRD
QDRNTRRMRR LANTAPAW