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SNF5_YEAST
ID   SNF5_YEAST              Reviewed;         905 AA.
AC   P18480; D6VQT4;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 3.
DT   03-AUG-2022, entry version 184.
DE   RecName: Full=SWI/SNF chromatin-remodeling complex subunit SNF5;
DE   AltName: Full=SWI/SNF complex subunit SNF5;
DE   AltName: Full=Transcription factor TYE4;
DE   AltName: Full=Transcription regulatory protein SNF5;
GN   Name=SNF5; Synonyms=SWI10, TYE4; OrderedLocusNames=YBR289W;
GN   ORFNames=YBR2036;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MCY;
RX   PubMed=2233708; DOI=10.1128/mcb.10.11.5616-5625.1990;
RA   Laurent B.C., Treitel M.A., Carlson M.;
RT   "The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-
RT   rich transcriptional activator that affects expression of a broad spectrum
RT   of genes.";
RL   Mol. Cell. Biol. 10:5616-5625(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8091861; DOI=10.1002/yea.320100007;
RA   Holmstroem K., Brandt T., Kallesoe T.;
RT   "The sequence of a 32,420 bp segment located on the right arm of chromosome
RT   II from Saccharomyces cerevisiae.";
RL   Yeast 10:S47-S62(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [4]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 564.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-818, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-818, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
RN   [9]
RP   3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, AND ELECTRON MICROSCOPY OF
RP   THE SWI/SNF COMPLEX.
RX   PubMed=12524530; DOI=10.1038/nsb888;
RA   Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L.,
RA   Peterson C.L.;
RT   "Structural analysis of the yeast SWI/SNF chromatin remodeling complex.";
RL   Nat. Struct. Biol. 10:141-145(2003).
CC   -!- FUNCTION: Involved in transcriptional activation. Component of the
CC       SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which
CC       is required for the positive and negative regulation of gene expression
CC       of a large number of genes. It changes chromatin structure by altering
CC       DNA-histone contacts within a nucleosome, leading eventually to a
CC       change in nucleosome position, thus facilitating or repressing binding
CC       of gene-specific transcription factors.
CC   -!- SUBUNIT: Component of the SWI/SNF global transcription activator
CC       complex. The 1.14 MDa SWI/SNF complex is composed of 11 different
CC       subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73,
CC       ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82;
CC       and three copies of TAF14/SWP29.
CC   -!- INTERACTION:
CC       P18480; P35189: TAF14; NbExp=2; IntAct=EBI-17546, EBI-18920;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 217 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the SNF5 family. {ECO:0000305}.
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DR   EMBL; M36482; AAA35062.1; -; Genomic_DNA.
DR   EMBL; X76053; CAA53652.1; -; Genomic_DNA.
DR   EMBL; Z36158; CAA85254.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA07404.2; -; Genomic_DNA.
DR   PIR; S44551; RGBYS5.
DR   RefSeq; NP_009848.4; NM_001178637.4.
DR   PDB; 6L9J; X-ray; 2.64 A; A/D/G/J=454-680.
DR   PDB; 6UXV; EM; 4.70 A; C=1-905.
DR   PDB; 6UXW; EM; 8.96 A; C=1-905.
DR   PDB; 7C4J; EM; 2.89 A; F=1-905.
DR   PDB; 7EG6; EM; 3.10 A; M=1-905.
DR   PDB; 7EGM; EM; 3.60 A; C=1-905.
DR   PDB; 7EGP; EM; 6.90 A; C=1-905.
DR   PDBsum; 6L9J; -.
DR   PDBsum; 6UXV; -.
DR   PDBsum; 6UXW; -.
DR   PDBsum; 7C4J; -.
DR   PDBsum; 7EG6; -.
DR   PDBsum; 7EGM; -.
DR   PDBsum; 7EGP; -.
DR   AlphaFoldDB; P18480; -.
DR   SMR; P18480; -.
DR   BioGRID; 32983; 510.
DR   ComplexPortal; CPX-1150; SWI/SNF chromatin remodelling complex.
DR   DIP; DIP-2364N; -.
DR   IntAct; P18480; 47.
DR   MINT; P18480; -.
DR   STRING; 4932.YBR289W; -.
DR   iPTMnet; P18480; -.
DR   MaxQB; P18480; -.
DR   PaxDb; P18480; -.
DR   PRIDE; P18480; -.
DR   EnsemblFungi; YBR289W_mRNA; YBR289W; YBR289W.
DR   GeneID; 852592; -.
DR   KEGG; sce:YBR289W; -.
DR   SGD; S000000493; SNF5.
DR   VEuPathDB; FungiDB:YBR289W; -.
DR   eggNOG; KOG1649; Eukaryota.
DR   GeneTree; ENSGT00440000038585; -.
DR   HOGENOM; CLU_011216_0_0_1; -.
DR   InParanoid; P18480; -.
DR   OMA; MIQQKHQ; -.
DR   BioCyc; YEAST:G3O-29208-MON; -.
DR   PRO; PR:P18480; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P18480; protein.
DR   GO; GO:0000785; C:chromatin; IC:ComplexPortal.
DR   GO; GO:0005829; C:cytosol; IDA:SGD.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0016514; C:SWI/SNF complex; IDA:SGD.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IMP:SGD.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0000436; P:carbon catabolite activation of transcription from RNA polymerase II promoter; IGI:SGD.
DR   GO; GO:0006338; P:chromatin remodeling; IDA:ComplexPortal.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:SGD.
DR   GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; IC:ComplexPortal.
DR   GO; GO:2000219; P:positive regulation of invasive growth in response to glucose limitation; IMP:SGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:SGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:ComplexPortal.
DR   InterPro; IPR006939; SNF5.
DR   Pfam; PF04855; SNF5; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; Nucleus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..905
FT                   /note="SWI/SNF chromatin-remodeling complex subunit SNF5"
FT                   /id="PRO_0000205955"
FT   REGION          50..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          664..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          847..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..88
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..109
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        684..698
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        886..905
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         818
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:18407956,
FT                   ECO:0007744|PubMed:19779198"
FT   CONFLICT        564
FT                   /note="D -> E (in Ref. 2; CAA53652 and 3; CAA85254)"
FT                   /evidence="ECO:0000305"
FT   HELIX           324..326
FT                   /evidence="ECO:0007829|PDB:7C4J"
FT   TURN            327..329
FT                   /evidence="ECO:0007829|PDB:7C4J"
FT   HELIX           334..356
FT                   /evidence="ECO:0007829|PDB:7C4J"
FT   HELIX           371..399
FT                   /evidence="ECO:0007829|PDB:7C4J"
FT   STRAND          422..428
FT                   /evidence="ECO:0007829|PDB:7C4J"
FT   STRAND          432..434
FT                   /evidence="ECO:0007829|PDB:7C4J"
FT   HELIX           442..449
FT                   /evidence="ECO:0007829|PDB:7C4J"
FT   STRAND          457..464
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   TURN            466..468
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   STRAND          469..471
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   STRAND          473..480
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   HELIX           488..495
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   TURN            496..498
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   HELIX           506..523
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   TURN            529..531
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   STRAND          543..552
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   STRAND          555..564
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   HELIX           572..582
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   HELIX           589..610
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   STRAND          615..617
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   HELIX           623..628
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   STRAND          637..639
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   HELIX           642..647
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   STRAND          651..654
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   HELIX           657..664
FT                   /evidence="ECO:0007829|PDB:6L9J"
FT   HELIX           666..679
FT                   /evidence="ECO:0007829|PDB:7EG6"
FT   STRAND          723..725
FT                   /evidence="ECO:0007829|PDB:7C4J"
FT   STRAND          737..739
FT                   /evidence="ECO:0007829|PDB:7C4J"
SQ   SEQUENCE   905 AA;  102543 MW;  F6D31A57E6D6DA94 CRC64;
     MNNQPQGTNS VPNSIGNIFS NIGTPSFNMA QIPQQLYQSL TPQQLQMIQQ RHQQLLRSRL
     QQQQQQQQQT SPPPQTHQSP PPPPQQSQPI ANQSATSTPP PPPAPHNLHP QIGQVPLAPA
     PINLPPQIAQ LPLATQQQVL NKLRQQAIAK NNPQVVNAIT VAQQQVQRQI EQQKGQQTAQ
     TQLEQQRQLL VQQQQQQQLR NQIQRQQQQQ FRHHVQIQQQ QQKQQQQQQQ HQQQQQQQQQ
     QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQGQ IPQSQQVPQV RSMSGQPPTN VQPTIGQLPQ
     LPKLNLPKYQ TIQYDPPETK LPYPTYWSDK KADTDTLLYE QIIQRDKINK YSLIRETNGY
     DPFSIYGFSN KEYISRLWHT LKYYQDLKNT RMKSITSTSQ KIPSASIWGN GYSGYGNGIT
     NTTTRVIPQV EVGNRKHYLE DKLKVYKQAM NETSEQLVPI RLEFDQDRDR FFLRDTLLWN
     KNDKLIKIED FVDDMLRDYR FEDATREQHI DTICQSIQEQ IQEFQGNPYI ELNQDRLGGD
     DLRIRIKLDI VVGQNQLIDQ FEWDISNSDN CPEEFAESMC QELELPGEFV TAIAHSIREQ
     VHMYHKSLAL LGYNFDGSAI EDDDIRSRML PTITLDDVYR PAAESKIFTP NLLQISAAEL
     ERLDKDKDRD TRRKRRQGRS NRRGMLALSG TSASNTSMNG VHNTVAAGNA SSLPPGEILL
     PDIADIPRTF RTPVPSTLMP GGVDVGPSVE SYELRNTTTY KSRPDRPKPV SPPCYIIDHI
     PGHSLLLSIK LPGKVNTKEE FAAAPNDTSS GTNAMLPSPE SLKTKLNSNI RAGVTIPSIP
     NPIANHTVTN SPNPTLQPVI PGGAASKSVP TPSLPIAPPV APHDSEATLL TNSNNGSSNN
     NTQNT
 
 
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