SNF7_ASHGO
ID SNF7_ASHGO Reviewed; 237 AA.
AC Q753W3;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Vacuolar-sorting protein SNF7;
DE AltName: Full=Vacuolar protein-sorting-associated protein 32;
GN Name=SNF7; Synonyms=VPS32; OrderedLocusNames=AFR209W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Required for the sorting and concentration of proteins
CC resulting in the entry of these proteins into the invaginating vesicles
CC of the multivesicular body (MVB). Also required for the proteolytic
CC cleavage of the transcription factor RIM101 in response to alkaline
CC ambient pH (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: A component of the endosomal sorting required for transport
CC complex III (ESCRT-III). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR EMBL; AE016819; AAS53580.1; -; Genomic_DNA.
DR RefSeq; NP_985756.1; NM_211110.1.
DR AlphaFoldDB; Q753W3; -.
DR SMR; Q753W3; -.
DR STRING; 33169.AAS53580; -.
DR EnsemblFungi; AAS53580; AAS53580; AGOS_AFR209W.
DR GeneID; 4622017; -.
DR KEGG; ago:AGOS_AFR209W; -.
DR eggNOG; KOG1656; Eukaryota.
DR HOGENOM; CLU_071097_1_0_1; -.
DR InParanoid; Q753W3; -.
DR OMA; WSWFGGA; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR GO; GO:0071454; P:cellular response to anoxia; IEA:EnsemblFungi.
DR GO; GO:1904902; P:ESCRT III complex assembly; IEA:EnsemblFungi.
DR GO; GO:0070676; P:intralumenal vesicle formation; IEA:EnsemblFungi.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR GO; GO:0061709; P:reticulophagy; IEA:EnsemblFungi.
DR GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR InterPro; IPR005024; Snf7_fam.
DR PANTHER; PTHR22761; PTHR22761; 1.
DR Pfam; PF03357; Snf7; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Endosome; Membrane; Reference proteome.
FT CHAIN 1..237
FT /note="Vacuolar-sorting protein SNF7"
FT /id="PRO_0000211436"
FT REGION 187..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 67..141
FT /evidence="ECO:0000255"
FT COMPBIAS 195..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 237 AA; 26685 MW; 2D8C60809A993B8E CRC64;
MWSYLFGSGN AKQKKELPKK AILELREHIQ LLSKKQAHLQ TQMTSQEESA RHFLSKGNKN
MAKAALKRKK VFESQLLKID KQVDSLEQQL YSIENANLNL ETMKAMKQGA SAMKHIHEGL
DVERVDETMD EIREQVELGE EISEAISRPL YTGVNEIDED ELDEELDMLA QEEVARKVME
PGAAVPAAAP ATKVSLPSVP SSDMPQQDRG QPVTLGMDQE EDEDERALRE LQAEMGL
