SNF7_CANAL
ID SNF7_CANAL Reviewed; 226 AA.
AC Q5ABD0; A0A1D8PCA5;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Vacuolar-sorting protein SNF7;
DE AltName: Full=Vacuolar protein-sorting-associated protein 32;
GN Name=SNF7; Synonyms=VPS32; OrderedLocusNames=CAALFM_C100650CA;
GN ORFNames=CaO19.13461, CaO19.6040;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION.
RX PubMed=15590834; DOI=10.1128/ec.3.6.1609-1618.2004;
RA Kullas A.L., Li M., Davis D.A.;
RT "Snf7p, a component of the ESCRT-III protein complex, is an upstream member
RT of the RIM101 pathway in Candida albicans.";
RL Eukaryot. Cell 3:1609-1618(2004).
CC -!- FUNCTION: Required for the sorting and concentration of proteins
CC resulting in the entry of these proteins into the invaginating vesicles
CC of the multivesicular body (MVB). Also required for the proteolytic
CC cleavage of the transcription factor RIM101 in response to alkaline
CC ambient pH. {ECO:0000269|PubMed:15590834}.
CC -!- SUBUNIT: A component of the endosomal sorting required for transport
CC complex III (ESCRT-III). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR EMBL; CP017623; AOW25763.1; -; Genomic_DNA.
DR RefSeq; XP_719002.1; XM_713909.1.
DR AlphaFoldDB; Q5ABD0; -.
DR SMR; Q5ABD0; -.
DR BioGRID; 1222471; 1.
DR STRING; 237561.Q5ABD0; -.
DR PRIDE; Q5ABD0; -.
DR GeneID; 3639377; -.
DR KEGG; cal:CAALFM_C100650CA; -.
DR CGD; CAL0000187201; SNF7.
DR VEuPathDB; FungiDB:C1_00650C_A; -.
DR eggNOG; KOG1656; Eukaryota.
DR HOGENOM; CLU_071097_1_0_1; -.
DR InParanoid; Q5ABD0; -.
DR OMA; WSWFGGA; -.
DR OrthoDB; 1490465at2759; -.
DR PRO; PR:Q5ABD0; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0000815; C:ESCRT III complex; IDA:CGD.
DR GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR GO; GO:0071454; P:cellular response to anoxia; IEA:EnsemblFungi.
DR GO; GO:0071285; P:cellular response to lithium ion; IMP:CGD.
DR GO; GO:0071467; P:cellular response to pH; IMP:CGD.
DR GO; GO:1904902; P:ESCRT III complex assembly; IEA:EnsemblFungi.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:0036178; P:filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
DR GO; GO:0036177; P:filamentous growth of a population of unicellular organisms in response to pH; IMP:CGD.
DR GO; GO:0031505; P:fungal-type cell wall organization; IMP:CGD.
DR GO; GO:0070676; P:intralumenal vesicle formation; IEA:EnsemblFungi.
DR GO; GO:0045324; P:late endosome to vacuole transport; IMP:CGD.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0016485; P:protein processing; IMP:CGD.
DR GO; GO:0006623; P:protein targeting to vacuole; IMP:CGD.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR GO; GO:0061709; P:reticulophagy; IEA:EnsemblFungi.
DR GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR InterPro; IPR005024; Snf7_fam.
DR PANTHER; PTHR22761; PTHR22761; 1.
DR Pfam; PF03357; Snf7; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Endosome; Membrane; Reference proteome.
FT CHAIN 1..226
FT /note="Vacuolar-sorting protein SNF7"
FT /id="PRO_0000211437"
FT REGION 168..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 18..182
FT /evidence="ECO:0000255"
SQ SEQUENCE 226 AA; 25890 MW; 9570B3B1E1C0419F CRC64;
MWGYFFGGNS QQKKDLPKKA IVELREHIQT LNKKKNHLQQ QMDDQDQLAR KYVSSKQTTL
AKSALKRKKG YESNLLKVEN QIETLETQLI SIEGANLNLE TMKAMKQGAK AMKQIHGEYD
VDKVEDTMDE IREQVELADE ISEAISRPVG NEFVDEDELD EELKELEAEA KEQEQEHRVP
AQKAKPQPVS REEELPQFPS VNKKAPVVEE DEDEEALKAL QAEMGL
