ID   SNF7_CANGA              Reviewed;         228 AA.
AC   Q6FW96;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Vacuolar-sorting protein SNF7;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 32;
GN   Name=SNF7; Synonyms=VPS32; OrderedLocusNames=CAGL0D01936g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the sorting and concentration of proteins
CC       resulting in the entry of these proteins into the invaginating vesicles
CC       of the multivesicular body (MVB). Also required for the proteolytic
CC       cleavage of the transcription factor RIM101 in response to alkaline
CC       ambient pH (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: A component of the endosomal sorting required for transport
CC       complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR380950; CAG58409.1; -; Genomic_DNA.
DR   RefSeq; XP_445498.1; XM_445498.1.
DR   AlphaFoldDB; Q6FW96; -.
DR   SMR; Q6FW96; -.
DR   STRING; 5478.XP_445498.1; -.
DR   EnsemblFungi; CAG58409; CAG58409; CAGL0D01936g.
DR   GeneID; 2887075; -.
DR   KEGG; cgr:CAGL0D01936g; -.
DR   CGD; CAL0128285; SNF7.
DR   VEuPathDB; FungiDB:CAGL0D01936g; -.
DR   eggNOG; KOG1656; Eukaryota.
DR   HOGENOM; CLU_071097_1_0_1; -.
DR   InParanoid; Q6FW96; -.
DR   OMA; WSWFGGA; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0000815; C:ESCRT III complex; IEA:EnsemblFungi.
DR   GO; GO:0005886; C:plasma membrane; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR   GO; GO:0071454; P:cellular response to anoxia; IEA:EnsemblFungi.
DR   GO; GO:1904902; P:ESCRT III complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0070676; P:intralumenal vesicle formation; IEA:EnsemblFungi.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR   GO; GO:0061709; P:reticulophagy; IEA:EnsemblFungi.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endosome; Membrane; Reference proteome.
FT   CHAIN           1..228
FT                   /note="Vacuolar-sorting protein SNF7"
FT                   /id="PRO_0000211438"
FT   REGION          171..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..200
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   228 AA;  25827 MW;  15A9885DEF954FE0 CRC64;
     MWASIFGGKG NTNKELPKKA IIELREHINL LSKKQAHLQG QITAQENEAR KFLTRGNKTM
     AKNALKKKKV YEGQLVKLES QMDSLEQQLF SIESANLNLE TMRAMKQGAK AMKSIHSGLD
     IDRVDETMDE IREQVELGEE ISDAISRPLY TGANEIDEDE LDEELDMLAQ ETEPQVATKE
     QALPESKQAL SMPNIPNTKI DESKTKIEEE EEDEDERALR ELQAEMGL